Medical Microbiology and Immunology

, Volume 190, Issue 4, pp 167–172 | Cite as

Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

  • A. Sauerbrei
  • A. Groh
  • A. Bischoff
  • J. Prager
  • P. Wutzler
Original Investigation

Abstract.

Maternal and cord blood samples of 290 pregnant women in the eastern part of Germany with a mean age of 28 years (16–41 years) were analyzed for antibodies to vaccine-preventable diseases. Both mothers and infants had detectable levels of antibodies to mumps in 96% and to tetanus in 93% of cases. Detectable levels to poliomyelitis, diphtheria, measles and rubella varied from 55% to 91%. Cord blood samples had a significantly higher prevalence of antibodies to pertussis (61%) and diphtheria (81%) in comparison to maternal samples (pertussis 37%, diphtheria 70%) as well as significantly enhanced antibody concentrations to diphtheria. In conclusion, the prevalence of antibodies to pertussis (61%), diphtheria (81%), poliomyelitis (55–59%) and measles (85%) is suggested to be insufficient in newborn infants to protect them against these infectious diseases.

Vaccination antibodies Pregnant women Cord blood Maternal antibodies Placental antibody transfer 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • A. Sauerbrei
    • 1
  • A. Groh
    • 2
  • A. Bischoff
    • 1
  • J. Prager
    • 3
  • P. Wutzler
    • 1
  1. 1.Institute for Antiviral Chemotherapy, Friedrich-Schiller University of Jena, Winzerlaer Strasse 10, 07745 Jena, GermanyGermany
  2. 2.Institute for Medical Microbiology, Friedrich-Schiller University of Jena, Semmelweisstrasse 4, 07740 Jena, GermanyGermany
  3. 3.Pediatric Clinic, Erzgebirgsklinikum Annaberg, Chemnitzer Strasse 15, 09456 Annaberg-Buchholz, GermanyGermany

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