Source-based morphometry: a decade of covarying structural brain patterns

  • Cota Navin GuptaEmail author
  • Jessica A. Turner
  • Vince D. Calhoun


In this paper, we review and discuss brain imaging studies which have used the source-based morphometry (SBM) approach over the past decade. SBM is a data-driven linear multivariate approach for decomposing structural brain imaging data into commonly covarying imaging components and subject-specific loading parameters. It is a well-established technique which has predominantly been used to study neuroanatomic differences between healthy controls and patients with neuropsychiatric diseases. We start by discussing the advantages of this technique over univariate analysis for imaging studies, followed by a discussion of results from recent studies which have successfully applied this methodology. We also present recent extensions of this framework including nonlinear SBM, biclustered independent component analysis (B-ICA) and conclude with the possible directions of work for future.


Independent component analysis (ICA) Source-based morphometry (SBM) Multivariate analysis Voxel-based morphometry (VBM) Univariate analysis Nonlinear independent component analysis (NICE) Biclustered independent component analysis (B-ICA) 



This work was supported by NIH 1R01MH094524 to Drs. Turner and Calhoun, as well as P20GM103472, 1R01EB006841, R01EB005846 and NSF grant 1539067 to Dr. Calhoun. The first author acknowledges support from the Indian Institute of Technology Guwahati startup grant during this work.

Compliance with ethical statement

Conflict of interest

The authors declare that they have no competing interests.

Ethical statement

This is a review article and human participants were not involved in this work.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory UniversityAtlantaUS
  2. 2.Neural Engineering Lab, Department of Biosciences and Bioengineering (BSBE)Indian Institute of Technology GuwahatiGuwahatiIndia
  3. 3.Department of Psychology and Neuroscience InstituteGeorgia State UniversityAtlantaUSA
  4. 4.Department of Electrical and Computer EngineeringUniversity of New MexicoAlbuquerqueUSA

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