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Sledge runner fasciculus: anatomic architecture and tractographic morphology

  • Christos KoutsarnakisEmail author
  • Aristotelis. V. Kalyvas
  • Georgios P. Skandalakis
  • Efstratios Karavasilis
  • Foteini Christidi
  • Spyridon Komaitis
  • George Velonakis
  • Faidon Liakos
  • John Emelifeonwu
  • Zoi Giavri
  • Theodosis Kalamatianos
  • Nikolaos Kelekis
  • George Stranjalis
Original Article

Abstract

The sledge runner fasciculus (SRF) has been recently identified as a discrete fiber tract of the occipital lobe and has been allegedly implicated in the axonal connectivity of cortical areas conveying spatial navigation and visuospatial imagery. However, detailed knowledge regarding its anatomic and tractographic morphology is lacking. We thus opted to investigate the anatomy and connectivity of the SRF through cadaveric dissections and DTI studies. Twenty normal, adult, cerebral, cadaveric hemispheres treated with the Klingler’s method were dissected through the fiber microdissection technique and 35 healthy participants from the MGH-USC Adult Diffusion Dataset (Human Connectome available dataset) underwent a tailored DTI protocol aiming to investigate the structural architecture of the SRF. SR was identified as a discrete fiber pathway, just under the U fibers of the medial occipital lobe, exhibiting a dorsomedial–ventrolateral trajectory and connecting the cortical areas of the anterior cuneus, anterior lingula, isthmus of the cingulum and posterior parahippocampal gyrus. The topography of the SR in relation to adjacent fiber pathways such as the cingulum, major forceps and stratum calcarinum is clearly delineated. Dissection and tractographic findings showed a good correspondence regarding SR topography, morphology and axonal connectivity. Our results support the hypothesis that the SRF is involved in the structural axonal connectivity of cerebral areas that strongly activate during spatial navigation and visuospatial imagery. Furthermore detailed anatomo-imaging evidence is provided on the microanatomic architecture of this newly discovered fiber tract.

Keywords

Sledge runner Brain connectivity White matter anatomy Occipital lobe Visuospatial imagery Spatial navigation 

Notes

Author contributions

Conception and design: CK, AVK. Acquisition of data: AVK, CK, GPS, FC, EK, NK, GV. Analysis and interpretation of data: AVK, CK, FC, EK, NK, FL, JE, ZG. Drafting the article: CK, AVK, FC, EK. Critically revising the article: CK, AVK, SK, TK, FL, JE, GS. Reviewed submitted version of manuscript: All authors. Administrative technical, material support: GS. Study supervision: CK.

Funding

No funding was received for this study.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest regarding the materials or methods used in the current study or the findings specified in this paper.

Informed consent

Informed consent was obtained from all participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Christos Koutsarnakis
    • 1
    • 2
    • 3
    • 7
    Email author
  • Aristotelis. V. Kalyvas
    • 1
    • 3
    • 7
  • Georgios P. Skandalakis
    • 1
    • 6
  • Efstratios Karavasilis
    • 4
  • Foteini Christidi
    • 4
    • 5
  • Spyridon Komaitis
    • 1
    • 3
    • 7
  • George Velonakis
    • 4
  • Faidon Liakos
    • 1
  • John Emelifeonwu
    • 1
    • 2
  • Zoi Giavri
    • 8
  • Theodosis Kalamatianos
    • 7
  • Nikolaos Kelekis
    • 4
  • George Stranjalis
    • 1
    • 3
    • 7
  1. 1.Athens Microneurosurgery LaboratoryEvangelismos HospitalAthensGreece
  2. 2.Edinburgh Microneurosurgery Education Laboratory, Department of Clinical NeurosciencesWestern General HospitalEdinburghUK
  3. 3.Department of Neurosurgery, Evangelismos HospitalNational and Kapodistrian University of AthensAthensGreece
  4. 4.2nd Department of Radiology, Medical SchoolGeneral University Hospital “Attikon”, National and Kapodistrian University of AthensAthensGreece
  5. 5.1st Department of Neurology, Medical School, Aeginition HospitalNational and Kapodistrian University of AthensAthensGreece
  6. 6.Medical SchoolNational and Kapodistrian University of AthensAthensGreece
  7. 7.Hellenic Center for Neurosurgical Research, “Petros Kokkalis”AthensGreece
  8. 8.Department of Electrical and Computer EngineeringNational Technical University of AthensAthensGreece

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