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Brain Structure and Function

, Volume 222, Issue 4, pp 1929–1944 | Cite as

Regional cerebellar volumetric correlates of manual motor and cognitive function

  • Vincent Koppelmans
  • Yoo Young Hoogendam
  • Sarah Hirsiger
  • Susan Mérillat
  • Lutz Jäncke
  • Rachael D. SeidlerEmail author
Original Article

Abstract

Cerebellar volume declines with aging. Few studies have investigated age differences in regional cerebellar volume (RCV) and their association with motor and cognitive function. In 213 healthy older adults, we investigated the association of age with motor skills, cognition and RCV. Subsequently, we studied the association of RCV with motor skills and cognition. RCVs were derived from T1-weighted MRI scans using the automated SUIT segmentation method and clustered using principal component analysis (PCA). Motor skill (manual dexterity, tapping speed, bimanual visuomotor coordination, grip force) and cognition (mental rotation, verbal memory, inhibition, mental flexibility) were assessed. Behavioral measures were clustered into compounds using PCA: left hand motor skill, right hand motor skill, verbal memory and mental flexibility, and mental rotation & inhibition. Volume of the rostral middle frontal gyri (rMFG) and premotor areas (PMA) were related to performance for reference. Analyses were adjusted for age, sex, and education. Volume of the cerebellar anterior lobe and top of the superior posterior lobe were positively associated with motor skill. Volume of the bottom part of the posterior superior lobe and the inferior posterior lobe was positively associated with cognition. PMA volume was associated with cognition and motor skill and rMFG volume with motor skill. Although these results did not survive FDR correction, their effect sizes suggest that regional cerebellar volume selectively contributes to cognitive and motor skill. Effect sizes of cerebellar associations with performance were similar to those of rMFG/PMA and performance suggesting parallel contributions to performance.

Keywords

Cerebellum Regional volume Aging MRI Cognition Motor skill 

Notes

Acknowledgments

VK was supported by a grant from the National Space Biomedical Research Institute (PF04101). YYH would like to thank the Stichting Fonds Dr. Catharine van Tussenbroek for their financial support. SM, SH and LJ are supported by the Velux-Stiftung (Project No. 369). This work was further supported by the University Research Priority Program (URPP) “Dynamics of Healthy Aging” of the University of Zurich. RS and LJ are members of the LIFE Course: Evolutionary and Ontogenetic Dynamics.

Compliance with ethical standards

Conflict of interest

All authors declare that the here-described research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Supplementary material

429_2016_1317_MOESM1_ESM.csv (5 kb)
Supplementary material 1 (CSV 5 kb)
429_2016_1317_MOESM2_ESM.csv (256 kb)
Supplementary material 2 (CSV 255 kb)

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© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.School of KinesiologyUniversity of MichiganAnn ArborUSA
  2. 2.International Normal Aging and Plasticity Imaging Center (INAPIC)University of ZurichZurichSwitzerland
  3. 3.University Research Priority Program “Dynamics of Healthy Aging”University of ZurichZurichSwitzerland
  4. 4.Division of NeuropsychologyUniversity of ZurichZurichSwitzerland
  5. 5.Department of Special EducationKing Abdulaziz UniversityJeddahSaudi Arabia
  6. 6.Department of PsychologyUniversity of MichiganAnn ArborUSA
  7. 7.Neuroscience ProgramUniversity of MichiganAnn ArborUSA
  8. 8.Institute of GerontologyUniversity of MichiganAnn ArborUSA

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