Brain Structure and Function

, Volume 221, Issue 4, pp 2075–2092 | Cite as

Subcomponents and connectivity of the superior longitudinal fasciculus in the human brain

  • Xuhui Wang
  • Sudhir Pathak
  • Lucia Stefaneanu
  • Fang-Cheng Yeh
  • Shiting Li
  • Juan C. Fernandez-Miranda
Original Article

Abstract

The subcomponents of the human superior longitudinal fasciculus (SLF) are disputed. The objective of this study was to investigate the segments, connectivity and asymmetry of the SLF. We performed high angular diffusion spectrum imaging (DSI) analysis on ten healthy adults. We also conducted fiber tracking on a 30-subject DSI template (CMU-30) and 488-subject template from the Human Connectome Project (HCP-488). In addition, five normal brains obtained at autopsy were microdissected. Based on tractography and microdissection results, we show that the human SLF differs significantly from that of monkey. The fibers corresponding to SLF-I found in 6 out of 20 hemispheres proved to be part of the cingulum fiber system in all cases and confirmed on both DSI and HCP-488 template. The most common patterns of connectivity bilaterally were as follows: from angular gyrus to caudal middle frontal gyrus and dorsal precentral gyrus representing SLF-II (or dorsal SLF), and from supramarginal gyrus to ventral precentral gyrus and pars opercularis to form SLF-III (or ventral SLF). Some connectivity features were, however, clearly asymmetric. Thus, we identified a strong asymmetry of the dorsal SLF (SLF-II), where the connectivity between the supramarginal gyrus with the dorsal precentral gyrus and the caudal middle frontal gyrus was only present in the left hemisphere. Contrarily, the ventral SLF (SLF-III) showed fairly constant connectivity with pars triangularis only in the right hemisphere. The results provide a novel neuroanatomy of the SLF that may help to better understand its functional role in the human brain.

Keywords

Superior longitudinal fasciculus Fiber tractography White matter Fiber tracts Arcuate fasciculus Microdissection 

Abbreviations

SLF

Superior longitudinal fasciculus

AF

Arcuate fasciculus

ROI

Region of interest

ROA

Region of avoidance

QA

Quantitative anisotropy

DSI

Diffusion spectrum imaging

Notes

Conflict of interest

None to declare.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Xuhui Wang
    • 1
    • 4
  • Sudhir Pathak
    • 2
  • Lucia Stefaneanu
    • 1
  • Fang-Cheng Yeh
    • 3
  • Shiting Li
    • 4
  • Juan C. Fernandez-Miranda
    • 1
  1. 1.Department of Neurological SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Learning Research and Development CenterUniversity of Pittsburgh School of MedicinePittsburghUSA
  3. 3.Department of Biomedical EngineeringCarnegie Mellon UniversityPittsburghUSA
  4. 4.Department of Neurological SurgeryXinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina

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