Dissociable attentional and inhibitory networks of dorsal and ventral areas of the right inferior frontal cortex: a combined task-specific and coordinate-based meta-analytic fMRI study
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The right inferior frontal cortex (rIFC) is frequently activated during executive control tasks. Whereas the function of the dorsal portion of rIFC, more precisely the inferior frontal junction (rIFJ), is convergingly assigned to the attention system, the functional key role of the ventral portion, i.e., the inferior frontal gyrus (rIFG), is hitherto controversially debated. Here, we used a two-step methodical approach to clarify the differential function of rIFJ and rIFG. First, we used event-related functional magnetic resonance imaging (fMRI) during a modified stop signal task with an attentional capture condition (acSST) to delineate attentional from inhibitory motor processes (step 1). Then, we applied coordinate-based meta-analytic connectivity modeling (MACM) to assess functional connectivity profiles of rIFJ and rIFG across various paradigm classes (step 2). As hypothesized, rIFJ activity was associated with the detection of salient stimuli, and was functionally connected to areas of the ventral and dorsal attention network. RIFG was activated during successful response inhibition even when controlling for attentional capture and revealed the highest functional connectivity with core motor areas. Thereby, rIFJ and rIFG delineated largely independent brain networks for attention and motor control. MACM results attributed a more specific attentional function to rIFJ, suggesting an integrative role between stimulus-driven ventral and goal-directed dorsal attention processes. In contrast, rIFG was disclosed as a region of the motor control but not attention system, being essential for response inhibition. The current study provides decisive evidence regarding a more precise functional characterization of rIFC subregions in attention and inhibition.
KeywordsAttentional capture Functional magnetic resonance imaging Meta-analytic connectivity modeling Right inferior frontal cortex Right inferior frontal junction Stop signal task
This work was supported by internal grants of the MAIFOR program and the research focus translational neurosciences (FTN) of the Johannes Gutenberg University Medical Center Mainz, Germany. Comprehensive access to the BrainMap database was authorized by a collaborative-use license agreement, provided to Simon Eickhoff by the University of Texas Health Science Center at San Antonio. BrainMap is supported by NIH/NIMH R01 MH074457. Findings presented in this study are part of the doctoral thesis of Jonathan Neuhoff.
- Bzdok D, Langner R, Schilbach L, Jakobs O, Roski C, Caspers S, Laird AR, Fox PT, Zilles K, Eickhoff SB (2013) Characterization of the temporo-parietal junction by combining data-driven parcellation, complementary connectivity analyses, and functional decoding. Neuroimage 81:381–392CrossRefPubMedPubMedCentralGoogle Scholar
- Chan AW, Downing PE (2011) Faces and eyes in human lateral prefrontal cortex. Front Hum, Neurosci 5Google Scholar
- Eickhoff SB, Laird AR, Grefkes C, Wang LE, Zilles K, Fox PT (2009) Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp 30:2907–2926CrossRefPubMedPubMedCentralGoogle Scholar
- First M, Spitzer R, Gibbon M, Williams J (1996) Structured Clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). American Psychiatric Press Inc, Washington, DCGoogle Scholar
- Jakobs O, Langner R, Caspers S, Roski C, Cieslik EC, Zilles K, Laird AR, Fox PT, Eickhoff SB (2012) Across-study and within-subject functional connectivity of a right temporo-parietal junction subregion involved in stimulus–context integration. NeuroImage 60:2389–2398CrossRefPubMedPubMedCentralGoogle Scholar
- Laird AR, Eickhoff SB, Fox PM, Uecker AM, Ray KL, Saenz JJ, McKay DR, Bzdok D, Laird RW, Robinson JL, Turner JA, Turkeltaub PE, Lancaster JL, Fox PT (2011) The BrainMap strategy for standardization, sharing, and meta-analysis of neuroimaging data. BMC Res Notes 4:349CrossRefPubMedPubMedCentralGoogle Scholar
- Rottschy C, Caspers S, Roski C, Reetz K, Dogan I, Schulz JB, Zilles K, Laird AR, Fox PT, Eickhoff SB (2013) Differentiated parietal connectivity of frontal regions for “what” and “where” memory. Brain Struct Funct 218(6):1551–1567. doi: 10.1007/s00429-012-0476-4 CrossRefPubMedPubMedCentralGoogle Scholar
- Wittchen H, Wunderlich U, Gruschwitz S, Zaudig M (1997) SKID-I. Strukturiertes Klinisches Interview für DSM-IV. Achse I: Psychische Störungen. Göttingen: HogrefeGoogle Scholar