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Brain Structure and Function

, Volume 221, Issue 2, pp 979–995 | Cite as

Considering structural connectivity in the triple code model of numerical cognition: differential connectivity for magnitude processing and arithmetic facts

  • Elise Klein
  • Julia Suchan
  • Korbinian Moeller
  • Hans-Otto Karnath
  • André Knops
  • Guilherme Wood
  • Hans-Christoph Nuerk
  • Klaus Willmes
Original Article

Abstract

The current study provides a generalizable account of the anatomo-functional associations as well as the connectivity of representational codes underlying numerical processing as suggested by the triple code model (TCM) of numerical cognition. By evaluating the neural networks subserving numerical cognition in two specific and substantially different numerical tasks with regard to both grey matter localizations as well as white matter tracts we (1) considered the possibility of additional memory-related cortex areas crucial for arithmetic fact retrieval (e.g., the hippocampus); (2) specified the functional involvement of prefrontal areas in number magnitude processing, and, finally; (3) identified the connections between these anatomo-functional instantiations of the representations involved in number magnitude processing and arithmetic fact retrieval employing probabilistic fiber tracking. The resulting amendments to the TCM are summarized in a schematic update, and ideas concerning the possible functional interplay between number magnitude processing and arithmetic fact retrieval are discussed.

Keywords

Diffusion tensor imaging fMRI Probabilistic fiber tracking Numerical cognition Triple code model 

Notes

Acknowledgments

This research was supported by the German Research Foundation (DFG) to Klaus Willmes (Wl 1804/6-1), Hans-Otto Karnath (KA 1258/11-1), Korbinian Moeller (MO 2525/2-1), and André Knops (KN 959/2-1) as well as by the Leibniz-Competition Fund (SAW) providing funding to Elise Klein (SAW-2014-IWM-4). We are indebted to the “Brain Imaging Facility of the Interdisciplinary Centre for Clinical Research within the Faculty of Medicine at the RWTH Aachen University” for their precious help in acquiring the MRI/fMRI data.

Supplementary material

429_2014_951_MOESM1_ESM.docx (3 mb)
Supplementary material 1 (DOCX 3066 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Elise Klein
    • 1
    • 2
  • Julia Suchan
    • 3
  • Korbinian Moeller
    • 1
    • 4
  • Hans-Otto Karnath
    • 3
  • André Knops
    • 5
  • Guilherme Wood
    • 6
  • Hans-Christoph Nuerk
    • 1
    • 4
  • Klaus Willmes
    • 2
  1. 1.Knowledge Media Research Center, Neurocognition LabIWM-KMRCTübingenGermany
  2. 2.Department of Neurology, Section NeuropsychologyUniversity Hospital, RWTH Aachen UniversityAachenGermany
  3. 3.Division of Neuropsychology, Center of Neurology, Hertie-Institute of Clinical Brain ResearchUniversity of TuebingenTübingenGermany
  4. 4.Institute of PsychologyEberhard Karls UniversityTübingenGermany
  5. 5.Department of PsychologyHumboldt-Universität zu BerlinBerlinGermany
  6. 6.Institute of PsychologyKarl-Franzens-University of GrazGrazAustria

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