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Brain Structure and Function

, Volume 221, Issue 1, pp 563–576 | Cite as

Where language meets meaningful action: a combined behavior and lesion analysis of aphasia and apraxia

  • Peter H. WeissEmail author
  • Simon D. Ubben
  • Stephanie Kaesberg
  • Elke Kalbe
  • Josef Kessler
  • Thomas Liebig
  • Gereon R. Fink
Original Article

Abstract

It is debated how language and praxis are co-represented in the left hemisphere (LH). As voxel-based lesion-symptom mapping in LH stroke patients with aphasia and/or apraxia may contribute to this debate, we here investigated the relationship between language and praxis deficits at the behavioral and lesion levels in 50 sub-acute stroke patients. We hypothesized that language and (meaningful) action are linked via semantic processing in Broca’s region. Behaviorally, half of the patients suffered from co-morbid aphasia and apraxia. While 24 % (n = 12) of all patients exhibited aphasia without apraxia, apraxia without aphasia was rare (n = 2, 4 %). Left inferior frontal, insular, inferior parietal, and superior temporal lesions were specifically associated with deficits in naming, reading, writing, or auditory comprehension. In contrast, lesions affecting the left inferior frontal gyrus, premotor cortex, and the central region as well as the inferior parietal lobe were associated with apraxic deficits (i.e., pantomime, imitation of meaningful and meaningless gestures). Thus, contrary to the predictions of the embodied cognition theory, lesions to sensorimotor and premotor areas were associated with the severity of praxis but not language deficits. Lesions of Brodmann area (BA) 44 led to combined apraxic and aphasic deficits. Data suggest that BA 44 acts as an interface between language and (meaningful) action thereby supporting parcellation schemes (based on connectivity and receptor mapping) which revealed a BA 44 sub-area involved in semantic processing.

Keywords

Broca’s region Brodmann areas Neuroanatomy Lesion mapping Stroke Neuropsychological assessment 

Abbreviation

ACA

Anterior cerebral artery

BA

Brodmann area

FWE

Family-wise error

IFG

Inferior frontal gyrus

IPL

Inferior parietal lobe

LH

Left hemisphere

MCA

Middle cerebral artery

MNI

Montreal neurological institute

MPM

Maximum probability map

PCA

Posterior cerebral artery

SMG

Supramarginal gyrus

SPM

Statistical parametric mapping

SPSS

Statistical package for the social sciences

STG

Superior temporal gyrus

VLSM

Voxel-based lesion-symptom mapping

WM

Working memory

Notes

Acknowledgments

The authors would like to thank their colleagues of the Cognitive Neuroscience division (INM-3), especially Dr. Anna Dovern. Support from the Marga and Walter Boll Stiftung to GRF is gratefully acknowledged.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Peter H. Weiss
    • 1
    • 2
    Email author
  • Simon D. Ubben
    • 1
    • 2
  • Stephanie Kaesberg
    • 2
    • 3
  • Elke Kalbe
    • 3
  • Josef Kessler
    • 2
  • Thomas Liebig
    • 4
  • Gereon R. Fink
    • 1
    • 2
  1. 1.Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3)Research Center JülichJülichGermany
  2. 2.Department of NeurologyUniversity Hospital CologneCologneGermany
  3. 3.Institute of Gerontology and Center for Neuropsychological Diagnostics and Intervention (CeNDI), Psychological GerontologyUniversity of VechtaVechtaGermany
  4. 4.Department of NeuroradiologyUniversity Hospital CologneCologneGermany

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