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Brain Structure and Function

, Volume 220, Issue 2, pp 1229–1236 | Cite as

The surface area of early visual cortex predicts the amplitude of the visual evoked potential

  • Torbjørn ElvsåshagenEmail author
  • Torgeir Moberget
  • Erlend Bøen
  • Per K. Hol
  • Ulrik F. Malt
  • Stein Andersson
  • Lars T. Westlye
Short Communication

Abstract

The extensive and increasing use of structural neuroimaging in the neurosciences rests on the assumption of an intimate relationship between structure and function in the human brain. However, few studies have examined the relationship between advanced magnetic resonance imaging (MRI) indices of cerebral structure and conventional measures of cerebral functioning in humans. Here we examined whether MRI-based morphometric measures of early visual cortex—estimated using a probabilistic anatomical mask of primary visual cortex (V1)—can predict the amplitude of the visual evoked potential (VEP), i.e., an electroencephalogram signal that primarily reflects postsynaptic potentials in early visual cortical areas. We found that left, right, and total V1 surface area positively predicted the VEP amplitude. In addition, we showed, using whole brain analysis of local surface areal expansion/contraction, that the association between VEP amplitude and surface area was highly specific for regions within bilateral V1. Together, these findings indicate a strong, selective relationship between MRI-based structural measures and functional properties of the human cerebral cortex.

Keywords

Magnetic resonance imaging Visual evoked potential Visual cortex Cortical thickness Cortical surface area 

Notes

Acknowledgments

This study was funded by the Research Council of Norway (167153/V50, 204966/F20), the South-Eastern Norway Regional Health Authority, and Oslo University Hospital—Rikshospitalet.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Torbjørn Elvsåshagen
    • 1
    • 5
    Email author
  • Torgeir Moberget
    • 1
    • 6
  • Erlend Bøen
    • 1
    • 5
  • Per K. Hol
    • 2
  • Ulrik F. Malt
    • 1
    • 5
  • Stein Andersson
    • 1
    • 6
  • Lars T. Westlye
    • 3
    • 4
    • 6
  1. 1.Department of Psychosomatic MedicineOslo University HospitalOsloNorway
  2. 2.The Intervention CentreOslo University HospitalOsloNorway
  3. 3.Norwegian Centre for Mental Disorders Research (NORMENT)Oslo University HospitalOsloNorway
  4. 4.KG Jebsen Centre for Psychosis ResearchOslo University HospitalOsloNorway
  5. 5.Institute of Clinical MedicineUniversity of OsloOsloNorway
  6. 6.Department of PsychologyUniversity of OsloOsloNorway

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