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Brain Structure and Function

, Volume 220, Issue 2, pp 745–762 | Cite as

Differentially disrupted functional connectivity of the subregions of the inferior parietal lobule in Alzheimer’s disease

  • Zhiqun Wang
  • Mingrui Xia
  • Zhengjia Dai
  • Xia Liang
  • Haiqing Song
  • Yong He
  • Kuncheng Li
Original Article

Abstract

Recent research on Alzheimer’s disease (AD) has shown that the altered structure and function of the inferior parietal lobule (IPL) provides a promising indicator of AD. However, little is known about the functional connectivity of the IPL subregions in AD subjects. In this study, we collected resting-state functional magnetic resonance imaging data from 32 AD patients and 38 healthy controls. We defined seven subregions of the IPL according to probabilistic cytoarchitectonic atlases and mapped the whole-brain resting-state functional connectivity for each subregion. Using hierarchical clustering analysis, we identified three distinct functional connectivity patterns of the IPL subregions: the anterior IPL connected with the sensorimotor network (SMN) and salience network (SN); the central IPL had connectivity with the executive-control network (ECN); and the posterior IPL exhibited connections with the default-mode network (DMN). Compared with the controls, the AD patients demonstrated distinct disruptive patterns of the IPL subregional connectivity with these different networks (SMN, SN, ECN and DMN), which suggests the impairment of the functional integration in the IPL. Notably, we also observed that the IPL subregions showed increased connectivity with the posterior part of the DMN in AD patients, which potentially indicates a compensatory mechanism. Finally, these abnormal IPL functional connectivity changes were closely associated with cognitive performance. Collectively, we show that the subregions of the IPL present distinct functional connectivity patterns with various functional networks that are differentially impaired in AD patients. Our results also suggest that functional disconnection and compensation in the IPL may coexist in AD.

Keywords

Supramarginal gyrus Angular gyrus Network fMRI Alzheimer disease 

Notes

Acknowledgments

This work was supported by the Natural Science Foundation of China (grant nos. 81030028, 81000606 and 81370037), the Beijing Natural Science Foundation (grant no. Z111107067311036 and Z101107052210002) and the National Science Fund for Distinguished Young Scholars (grant no. 81225012).

Conflict of interest

The authors declare no competing financial interests.

Supplementary material

429_2013_681_MOESM1_ESM.docx (20 kb)
Supplementary material 1 (DOCX 20 kb)
429_2013_681_MOESM2_ESM.tif (3.7 mb)
Supplementary material 2 (TIFF 3809 kb)

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of RadiologyXuanwu Hospital of Capital Medical UniversityBeijingChina
  2. 2.State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijingChina
  3. 3.Center for Collaboration and Innovation in Brain and Learning SciencesBeijing Normal UniversityBeijingChina
  4. 4.Department of NeurologyXuanwu Hospital of Capital Medical UniversityBeijingChina
  5. 5.Key Laboratory for Neurodegenerative DiseasesCapital Medical University, Ministry of EducationBeijingChina
  6. 6.Beijing Key Laboratory of Magnetic Resonance Imaging and Brain InformaticsBeijingChina

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