Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus
- 514 Downloads
Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0 years, respectively) participants. According to the tinnitus questionnaire (TQ) score grade, LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD–LOT participants than in LD–LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dorsolateral prefrontal cortex were activated more in HD–EOT than in LD–EOT for the delta/beta and gamma frequency bands, respectively. Even with the same amount of tinnitus-related distress level, responsible neural substrates are different according to the onset age. These differences may be important for exploring different target areas of treatment according to tinnitus onset age, as well as for conducting similar studies on other pathologies, such as depression or pain.
KeywordsTinnitus Anxiety Aging Electroencephalography Gyrus cinguli Prefrontal cortex
The authors thank Jan Ost, Bram Van Achteren, Bjorn Devree, Pieter van Looy for their help in preparing this manuscript. Also, the first author thanks to Dr. DY Yoon for giving precious support to the study. This work was supported by Research Foundation Flanders (FWO), Tinnitus Research Initiative, The Neurological Foundation of New Zealand, TOP project University Antwerp, the Korean Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (no. 2012-0030102), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A6A3A03038293).
- Dierks T, Jelic V, Pascual-Marqui RD, Wahlund L, Julin P, Linden DE, Maurer K, Winblad B, Nordberg A (2000) Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer’s disease. Clin Neurophysiol 111:1817–1824PubMedCrossRefGoogle Scholar
- Pascual-Marqui RD (2002) Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol 24 Suppl D:5–12Google Scholar
- Pascual-Marqui RD (2007) Instantaneous and lagged measurements of linear and nonlinear dependence between groups of multivariate time series: frequency decomposition. Arxiv preprint arXiv:07111455Google Scholar
- Pizzagalli D, Pascual-Marqui RD, Nitschke JB, Oakes TR, Larson CL, Abercrombie HC, Schaefer SM, Koger JV, Benca RM, Davidson RJ (2001) Anterior cingulate activity as a predictor of degree of treatment response in major depression: evidence from brain electrical tomography analysis. Am J Psychiatry 158:405–415PubMedCrossRefGoogle Scholar
- Song JJ, De Ridder D, Weisz N, Schlee W, Van de Heyning P, Vanneste S (2013b) Hyperacusis-associated pathological resting-state brain oscillations in the tinnitus brain: a hyperresponsiveness network with paradoxically inactive auditory cortex. Brain Struct FunctGoogle Scholar
- Taki Y, Thyreau B, Kinomura S, Sato K, Goto R, Wu K, Kawashima R, Fukuda H (2012) A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults. Hum Brain MappGoogle Scholar