Brain Structure and Function

, Volume 218, Issue 4, pp 951–968 | Cite as

Human middle longitudinal fascicle: variations in patterns of anatomical connections

  • N. Makris
  • M. G. Preti
  • T. Asami
  • P. Pelavin
  • B. Campbell
  • G. M. Papadimitriou
  • J. Kaiser
  • G. Baselli
  • C. F. Westin
  • M. E. Shenton
  • M. Kubicki
Original Article

Abstract

Based on high-resolution diffusion tensor magnetic resonance imaging (DTI) tractographic analyses in 39 healthy adult subjects, we derived patterns of connections and measures of volume and biophysical parameters, such as fractional anisotropy (FA) for the human middle longitudinal fascicle (MdLF). Compared to previous studies, we found that the cortical connections of the MdLF in humans appear to go beyond the superior temporal (STG) and angular (AG) gyri, extending to the temporal pole (TP), superior parietal lobule (SPL), supramarginal gyrus, precuneus and the occipital lobe (including the cuneus and lateral occipital areas). Importantly, the MdLF showed a striking lateralized pattern with predominant connections between the TP, STG and AG on the left and TP, STG and SPL on the right hemisphere. In light of the results of the present study, and of the known functional role of the cortical areas interconnected by the MdLF, we suggested that this fiber pathway might be related to language, high order auditory association, visuospatial and attention functions.

Keywords

Diffusion tensor tractography Middle longitudinal fascicle Angular gyrus Superior parietal lobule Superior temporal gyrus Language 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • N. Makris
    • 1
    • 2
    • 3
  • M. G. Preti
    • 4
    • 5
  • T. Asami
    • 2
  • P. Pelavin
    • 2
  • B. Campbell
    • 1
  • G. M. Papadimitriou
    • 1
  • J. Kaiser
    • 1
  • G. Baselli
    • 4
  • C. F. Westin
    • 7
  • M. E. Shenton
    • 2
    • 6
  • M. Kubicki
    • 2
  1. 1.Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, A. Martinos Center for Biomedical ImagingMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Psychiatry Neuroimaging Laboratory, Department of PsychiatryBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Department of Anatomy and NeurobiologyBoston University School of MedicineBostonUSA
  4. 4.Department of BioengineeringPolitecnico di MilanoMilanItaly
  5. 5.Magnetic Resonance LaboratoryDon Gnocchi FoundationMilanItaly
  6. 6.Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton DivisionHarvard Medical SchoolBrocktonUSA
  7. 7.Laboratory of Mathematics in Imaging, Surgical Planning Laboratory, MRI Division, Department of RadiologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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