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Brain Structure and Function

, Volume 218, Issue 3, pp 711–720 | Cite as

Morphometry of corpus callosum in Williams syndrome: shape as an index of neural development

  • Adriana Sampaio
  • Sylvain Bouix
  • Nuno Sousa
  • Cristiana Vasconcelos
  • Montse Férnandez
  • Martha E. Shenton
  • Óscar F. Gonçalves
Original Article

Abstract

Brain abnormalities in Williams syndrome (WS) have been consistently reported, despite few studies have devoted attention to connectivity between different brain regions in WS. In this study, we evaluated corpus callosum (CC) morphometry: bending angle, length, thickness and curvature of CC using a new shape analysis method in a group of 17 individuals with WS matched with a typically developing group. We used this multimethod approach because we hypothesized that neurodevelopmental abnormalities might result in both volume changes and structure deformation. Overall, we found reduced absolute CC cross-sectional area and volume in WS (mean CC and subsections). In parallel, we observed group differences regarding CC shape and thickness. Specifically, CC of WS is morphologically different, characterized by a larger bending angle and being more curved in the posterior part. Moreover, although CC in WS is shorter, a larger relative thickness of CC was found in all callosal sections. Finally, groups differed regarding the association between CC measures, age, white matter volume and cognitive performance. In conclusions, abnormal patterns of CC morphology and shape may be implicated in WS cognitive and behavioural phenotype.

Keywords

Corpus callosum MRI Neurodevelopment Williams syndrome 

Notes

Acknowledgments

This research was supported by the grants PIC/IC/83290/2007 and PTDC/PSI-PCL/115316/2009 from Fundação para a Ciência e Tecnologia (Portugal). This study was also supported, in part, by grants from the National Institutes of Health (K05 MH070047).

Conflict of interest

The authors report no conflicts of interest.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Adriana Sampaio
    • 1
  • Sylvain Bouix
    • 3
  • Nuno Sousa
    • 2
  • Cristiana Vasconcelos
    • 4
  • Montse Férnandez
    • 5
  • Martha E. Shenton
    • 3
    • 6
  • Óscar F. Gonçalves
    • 1
  1. 1.Neuropsychophysiology Laboratory, CiPsi, School of PsychologyUniversity of MinhoBragaPortugal
  2. 2.Life and Health Sciences Research InstituteUniversity of MinhoBragaPortugal
  3. 3.Psychiatry Neuroimaging Laboratory, Department of PsychiatryBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  4. 4.Department of NeuroradiologyHospital de Santo AntónioPortoPortugal
  5. 5.Genetic Molecular Unit, Galician Public Foundation of Genomic Medicine, University of Santiago de CompostelaSantiago de CompostelaSpain
  6. 6.Laboratory of Neuroscience, Clinical Neuroscience Division, Department of PsychiatryVA Boston Healthcare System, and Harvard Medical SchoolBrocktonUSA

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