Brain Structure and Function

, Volume 214, Issue 5–6, pp 563–577 | Cite as

The sentient self

  • A. D. (Bud) CraigEmail author
Special Issue


This article addresses the neuroanatomical evidence for a progression of integrative representations of affective feelings from the body that lead to an ultimate representation of all feelings in the bilateral anterior insulae, or “the sentient self.” Evidence for somatotopy in the primary interoceptive sensory cortex is presented, and the organization of the mid-insula and the anterior insula is discussed. Issues that need to be addressed are highlighted. A possible basis for subjectivity in a cinemascopic model of awareness is presented.


Insula Emotion Feelings Awareness 


  1. Ackermann H, Riecker A (2004) The contribution of the insula to motor aspects of speech production: a review and a hypothesis. Brain Lang 89:320–328PubMedCrossRefGoogle Scholar
  2. Ackermann H, Riecker A (2010) The contribution(s) of the insula to speech communication: a review of the clinical and functional imaging literature. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0257-x
  3. Adolphs R (2002) Trust in the brain. Nat Neurosci 5:192–193PubMedCrossRefGoogle Scholar
  4. Allman JM, Watson KK, Tetreault NA, Hakeem AY (2005) Intuition and autism: a possible role for Von Economo neurons. Trends Cogn Sci 9:367–373PubMedCrossRefGoogle Scholar
  5. Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K, Erwin JM, Park S, Goubert V, Hof PR (2010) The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0254-0
  6. Baliki MN, Geha PY, Apkarian AV (2009) Parsing pain perception between nociceptive representation and magnitude estimation. J Neurophysiol 101:875–887PubMedCrossRefGoogle Scholar
  7. Barrett LF, Bar M (2009) See it with feeling: affective predictions during object perception. Philos Trans R Soc Lond B Biol Sci 364:1325–1334PubMedCrossRefGoogle Scholar
  8. Bass AH, Gilland EH, Baker R (2008) Evolutionary origins for social vocalization in a vertebrate hindbrain-spinal compartment. Science 321:417–421PubMedCrossRefGoogle Scholar
  9. Bassetti C, Bogousslavsky J, Regli F (1993) Sensory syndromes in parietal stroke. Neurology 43:1942–1949PubMedGoogle Scholar
  10. Baumgartner U, Tiede W, Treede RD, Craig AD (2006) Laser-evoked potentials are graded and somatotopically organized anteroposteriorly in the operculoinsular cortex of anesthetized monkeys. J Neurophysiol 96:2802–2808PubMedCrossRefGoogle Scholar
  11. Berman S, Munakata J, Naliboff BD, Chang L, Mandelkern M, Silverman D, Kovalik E, Mayer EA (2000) Gender differences in regional brain response to visceral pressure in IBS patients. Eur J Pain 4:157–172PubMedCrossRefGoogle Scholar
  12. Biemond A (1956) The conduction of pain above the level of the thalamus opticus. Arch Neurol Psychiatry 75:231–244Google Scholar
  13. Birklein F, Rolke R, Müller-Forell W (2005) Isolated insular infarction eliminates contralateral cold, cold pain, and pinprick perception. Neurology 65:1381PubMedCrossRefGoogle Scholar
  14. Bjornsdotter M, Loken L, Olausson H, Vallbo A, Wessberg J (2009) Somatotopic organization of gentle touch processing in the posterior insular cortex. J Neurosci 29:9314–9320PubMedCrossRefGoogle Scholar
  15. Brass M, Haggard P (2007) To do or not to do: the neural signature of self-control. J Neurosci 27:9141–9145PubMedCrossRefGoogle Scholar
  16. Brooks JC, Nurmikko TJ, Bimson WE, Singh KD, Roberts N (2002) fMRI of thermal pain: effects of stimulus laterality and attention. Neuroimage 15:293–301PubMedCrossRefGoogle Scholar
  17. Brooks JC, Zambreanu L, Godinez A, Craig AD, Tracey I (2005) Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. Neuroimage 27:201–209PubMedCrossRefGoogle Scholar
  18. Burton H, Videen TO, Raichle ME (1993) Tactile-vibration-activated foci in insular and parietal- opercular cortex studied with positron emission tomography: Mapping the second somatosensory area in humans. Somatosens Mot Res 10:297–308PubMedCrossRefGoogle Scholar
  19. Buzsaki G (2006) Rhythms of the brain. Oxford University Press, New YorkCrossRefGoogle Scholar
  20. Cacioppo JT, Larsen JT, Smith NK, Berntson GG (2004) The affect system: what lurks below the surface of feelings? In: Manstead ASR, Frijda NH, Fischer AH (eds) Feelings and emotions: The Amsterdam Conference. Cambridge University Press, New York, pp 223–242Google Scholar
  21. Cappa S, Sterzi R, Vallar G, Bisiach E (1987) Remission of hemineglect and anosognosia during vestibular stimulation. Neuropsychologia 25:775–782PubMedCrossRefGoogle Scholar
  22. Carr L, Iacoboni M, Dubeau MC, Mazziotta JC, Lenzi GL (2003) Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci USA 100:5497–5502PubMedCrossRefGoogle Scholar
  23. Chikama M, McFarland NR, Amaral DG, Haber SN (1997) Insular cortical projections to functional regions of the striatum correlate with cortical cytoarchitectonic organization in the primate. J Neurosci 17:9686–9705PubMedGoogle Scholar
  24. Christensen MS, Ramsoy TZ, Lund TE, Madsen KH, Rowe JB (2006) An fMRI study of the neural correlates of graded visual perception. Neuroimage 31:1711–1725PubMedCrossRefGoogle Scholar
  25. Cole MW, Schneider W (2007) The cognitive control network: integrated cortical regions with dissociable functions. Neuroimage 37:343–360PubMedCrossRefGoogle Scholar
  26. Craig AD (2002) How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 3:655–666PubMedGoogle Scholar
  27. Craig AD (2004a) Distribution of trigeminothalamic and spinothalamic lamina I terminations in the macaque monkey. J Comp Neurol 477:119–148PubMedCrossRefGoogle Scholar
  28. Craig AD (2004b) A new view of pain as a homeostatic emotion. Trends Neurosci 26:303–307CrossRefGoogle Scholar
  29. Craig AD (2005) Forebrain emotional asymmetry: a neuroanatomical basis? Trends Cogn Sci 9:566–571PubMedCrossRefGoogle Scholar
  30. Craig AD (2008) Interoception and emotion: a neuroanatomical perspective. In: Lewis M, Haviland-Jones JM, Barrett LF (eds) Handbook of emotions, 3rd edn. Guilford Publications, New York, pp 272–288Google Scholar
  31. Craig AD (2009a) How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci 10:59–70PubMedCrossRefGoogle Scholar
  32. Craig AD (2009b) Disembodied hallucinatory voices (comment on Sommer et al., 2008 Brain 131, 3169–3177). Brain 132:e123CrossRefGoogle Scholar
  33. Craig AD, Krout K, Zhang E-T (1995) Cortical projections of VMpo, a specific pain and temperature relay in primate thalamus. Soc Neurosci Abstr 21:1165Google Scholar
  34. Craig AD, Chen K, Bandy D, Reiman EM (2000) Thermosensory activation of insular cortex. Nat Neurosci 3:184–190PubMedCrossRefGoogle Scholar
  35. Craig AD, Krout K, Andrew D (2001) Quantitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat. J Neurophysiol 86:1459–1480Google Scholar
  36. Critchley HD, Mathias CJ, Dolan RJ (2002) Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy. Neuron 33:653–663PubMedCrossRefGoogle Scholar
  37. Damasio AR (1994) Descartes’ error: emotion, reason, and the human brain. Putnam, New YorkGoogle Scholar
  38. Damasio AR, Grabowski TJ, Bechara A, Damasio H, Ponto LL, Parvizi J, Hichwa RD (2000) Subcortical and cortical brain activity during the feeling of self-generated emotions. Nat Neurosci 3:1049–1056PubMedCrossRefGoogle Scholar
  39. Deary IJ, Simonotto E, Meyer M, Marshall A, Marshall I, Goddard N, Wardlaw JM (2004) The functional anatomy of inspection time: an event-related fMRI study. Neuroimage 22:1466–1479PubMedCrossRefGoogle Scholar
  40. Dehaene S, Sergent C, Changeux JP (2003) A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proc Natl Acad Sci USA 100:8520–8525PubMedCrossRefGoogle Scholar
  41. Del Parigi A, Chen K, Salbe AD, Gautier JF, Ravussin E, Reiman EM, Tataranni PA (2002) Tasting a liquid meal after a prolonged fast is associated with preferential activation of the left hemisphere. NeuroReport 13:1141–1145PubMedCrossRefGoogle Scholar
  42. Dennett DC (2003) The self as a responding-and responsible-artifact. Ann N Y Acad Sci 1001:39–50PubMedCrossRefGoogle Scholar
  43. Devue C, Collette F, Balteau E, Degueldre C, Luxen A, Maquet P, Bredart S (2007) Here I am: the cortical correlates of visual self-recognition. Brain Res 1143:169–182PubMedCrossRefGoogle Scholar
  44. Dostrovsky JO, Craig AD (1996) Nociceptive neurons in primate insular cortex. Soc Neurosci Abstr 22:111Google Scholar
  45. Dronkers NF (1996) A new brain region for coordinating speech articulation. Nature 384:159–161PubMedCrossRefGoogle Scholar
  46. Egan G, Silk T, Zamarripa F, Williams J, Federico P, Cunnington R, Carabott L, Blair-West J, Shade R, McKinley M, Farrell M, Lancaster J, Jackson G, Fox P, Denton D (2003) Neural correlates of the emergence of consciousness of thirst. Proc Natl Acad Sci USA 100:15241–15246PubMedCrossRefGoogle Scholar
  47. Farrer C, Frey SH, Van Horn JD, Tunik E, Turk D, Inati S, Grafton ST (2008) The angular gyrus computes action awareness representations. Cereb Cortex 18:254–261PubMedCrossRefGoogle Scholar
  48. Fink GR, Frackowiak RSJ, Pietrzyk U, Passingham RE (1997) Multiple nonprimary motor areas in the human cortex. J Neurophysiol 77:2164–2174PubMedGoogle Scholar
  49. Frank GK, Oberndorfer TA, Simmons AN, Paulus MP, Fudge JL, Yang TT, Kaye WH (2008) Sucrose activates human taste pathways differently from artificial sweetener. Neuroimage 39:1559–1569PubMedCrossRefGoogle Scholar
  50. Friedman DP, Murray EA, O’Neill JB, Mishkin M (1986) Cortical connections of the somatosensory fields of the lateral sulcus of macaques: evidence for a corticolimbic pathway for touch. J Comp Neurol 252:323–347PubMedCrossRefGoogle Scholar
  51. Frith CD, Frith U (2007) Social cognition in humans. Curr Biol 17:R724–R732PubMedCrossRefGoogle Scholar
  52. Fudge JL, Breitbart MA, Danish M, Pannoni V (2005) Insular and gustatory inputs to the caudal ventral striatum in primates. J Comp Neurol 490:101–118PubMedCrossRefGoogle Scholar
  53. Greenspan JD, Lee RR, Lenz FA (1999) Pain sensitivity alterations as a function of lesion location in the parasylvian cortex. Pain 81:273–282PubMedCrossRefGoogle Scholar
  54. Griffiths TD, Warren JD, Dean JL, Howard D (2004) “When the feeling’s gone”: a selective loss of musical emotion. J Neurol Neurosurg Psychiatry 75:344–345PubMedGoogle Scholar
  55. Grudnik JL, Kranzler JH (2001) Meta-analysis of the relationship between intelligence and inspection time. Intelligence 29:523–535CrossRefGoogle Scholar
  56. Heilman KM (2000) Emotional experience: a neurological model. In: Lane RD, Nadel L (eds) Cognitive neuroscience of emotion. Oxford University Press, New York, pp 328–344Google Scholar
  57. Henderson LA, Gandevia SC, Macefield VG (2007) Somatotopic organization of the processing of muscle and cutaneous pain in the left and right insula cortex: a single-trial fMRI study. Pain 128:20–30PubMedCrossRefGoogle Scholar
  58. Hodgson T, Chamberlain M, Parris B, James M, Gutowski N, Husain M, Kennard C (2007) The role of the ventrolateral frontal cortex in inhibitory oculomotor control. Brain 130:1525–1537PubMedCrossRefGoogle Scholar
  59. Hua LH, Strigo IA, Baxter LC, Johnson SC, Craig AD (2005) Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex. Am J Physiol Regul Integr Comp Physiol 289:R319–R325Google Scholar
  60. Huang J, Craig AD (2008) Multiple laser evoked potential sources in the neighborhood of the operculoinsular cortex of the anesthetized macaque monkey. Soc Neurosci (Online)Google Scholar
  61. Ibañez A, Gleichgerrcht E, Manes F (2010) Clinical effects of insular damage in humans. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0256-y
  62. Jabbi M, Bastiaansen J, Keysers C (2008) A common anterior insula representation of disgust observation, experience and imagination shows divergent functional connectivity pathways. PLoS ONE 3:e2939PubMedCrossRefGoogle Scholar
  63. Jackson PL, Brunet E, Meltzoff AN, Decety J (2006) Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia 44:752–761PubMedCrossRefGoogle Scholar
  64. Johnson JI, Buchanan KJ, Morris JA, Fobbs AJ (2009) Interrelation of gyral formations, cytoarchitectural variations, and sensory regions in human insular cortex. Soc Neurosci (Online)Google Scholar
  65. Karnath HO, Baier B (2010) Right insula for our sense of limb ownership and self-awareness of actions. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0250-4
  66. Karnath HO, Baier B, Nagele T (2005) Awareness of the functioning of one’s own limbs mediated by the insular cortex? J Neurosci 25:7134–7138PubMedCrossRefGoogle Scholar
  67. Kikyo H, Ohki K, Miyashita Y (2002) Neural correlates for feeling-of-knowing: an fMRI parametric analysis. Neuron 36:177–186PubMedCrossRefGoogle Scholar
  68. Klein TA, Endrass T, Kathmann N, Neumann J, von Cramon DY, Ullsperger M (2007) Neural correlates of error awareness. Neuroimage 34:1774–1781PubMedCrossRefGoogle Scholar
  69. Koelsch S, Fritz T, VC DY, Muller K, Friederici AD (2006) Investigating emotion with music: an fMRI study. Hum Brain Mapp 27:239–250PubMedCrossRefGoogle Scholar
  70. Kranczioch C, Debener S, Schwarzbach J, Goebel R, Engel AK (2005) Neural correlates of conscious perception in the attentional blink. Neuroimage 24:704–714PubMedCrossRefGoogle Scholar
  71. Laird JM (2007) Feelings. Oxford University Press, New YorkCrossRefGoogle Scholar
  72. Lamm C, Singer T (2010) The role of anterior insular cortex in social emotions. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0251-3
  73. Leonard WR, Robertson ML, Snodgrass JJ, Kuzawa CW (2003) Metabolic correlates of hominid brain evolution. Comp Biochem Physiol A Mol Integr Physiol 136:5–15PubMedCrossRefGoogle Scholar
  74. Lewis M (2008) The emergence of human emotions. In: Lewis M, Haviland-Jones JM, Barrett LF (eds) Handbook of emotions, 3rd edn. Guilford Press, New York, pp 304–319Google Scholar
  75. Livesey AC, Wall MB, Smith AT (2007) Time perception: manipulation of task difficulty dissociates clock functions from other cognitive demands. Neuropsychologia 45:321–331PubMedCrossRefGoogle Scholar
  76. Macneilage PF, Rogers LJ, Vallortigara G (2009) Origins of the left and right brain. Sci Am 301:60–67PubMedCrossRefGoogle Scholar
  77. Mazzola L, Isnard J, Peyron R, Guenot M, Mauguiere F (2009) Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortex. Pain 146:99–104PubMedCrossRefGoogle Scholar
  78. Menon V, Levitin DJ (2005) The rewards of music listening: response and physiological connectivity of the mesolimbic system. Neuroimage 28:175–184PubMedCrossRefGoogle Scholar
  79. Michelon P, Snyder AZ, Buckner RL, McAvoy M, Zacks JM (2003) Neural correlates of incongruous visual information. An event-related fMRI study. Neuroimage 19:1612–1626PubMedCrossRefGoogle Scholar
  80. Moayedi M, Weissman-Fogel I (2009) Is the insula the “how much” intensity coder? J Neurophysiol 102:1345–1347PubMedCrossRefGoogle Scholar
  81. Mufson EJ, Sobreviela T, Kordower JH (1997) Chemical neuroanatomy of the primate insula cortex: relationship to cytoarchitectonics, connectivity, function and neurodegeneration. In: Bloom FE, Bjorklund A, Hokfelt T (eds) Handbook of chemical neuroanatomy, vol 13. The primate nervous system, part I. Elsevier, Amsterdam, pp 377–454Google Scholar
  82. Mutschler I, Schulze-Bonhage A, Glauche V, Demandt E, Speck O, Ball T (2007) A rapid sound-action association effect in human insular cortex. PLoS ONE 2:e259PubMedCrossRefGoogle Scholar
  83. Mutschler I, Wieckhorst B, Kowalevski S, Derix J, Wentlandt J, Schulze-Bonhage A, Ball T (2009) Functional organization of the human anterior insular cortex. Neurosci Lett 457:66–70PubMedCrossRefGoogle Scholar
  84. Naidich TP, Kang E, Fatterpekar GM, Delman BN, Gultekin SH, Wolfe D, Ortiz O, Yousry I, Weismann M, Yousry TA (2004) The insula: anatomic study and MR imaging display at 1.5 T. AJNR Am J Neuroradiol 25:222–232PubMedGoogle Scholar
  85. Olausson H, Lamarre Y, Backlund H, Morin C, Wallin BG, Starck G, Ekholm S, Strigo I, Worsley K, Vallbo AB, Bushnell MC (2002) Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci 5:900–904PubMedCrossRefGoogle Scholar
  86. Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC (1992) Cardiovascular effects of human insular cortex stimulation. Neurology 42:1727–1732PubMedGoogle Scholar
  87. Orfei MD, Robinson RG, Prigatano GP, Starkstein S, Rusch N, Bria P, Caltagirone C, Spalletta G (2007) Anosognosia for hemiplegia after stroke is a multifaceted phenomenon: a systematic review of the literature. Brain 130:3075–3090PubMedCrossRefGoogle Scholar
  88. Ortigue S, Grafton ST, Bianchi-Demicheli F (2007) Correlation between insula activation and self-reported quality of orgasm in women. Neuroimage 37:551–560PubMedCrossRefGoogle Scholar
  89. Pelchat ML, Johnson A, Chan R, Valdez J, Ragland JD (2004) Images of desire: food-craving activation during fMRI. Neuroimage 23:1486–1493PubMedCrossRefGoogle Scholar
  90. Penfield W, Rasmussen T (1968) The cerebral cortex of man: a clinical study of localization of function. Hafner Publishing Company, New York, p 1Google Scholar
  91. Picard F, Craig AD (2009) Ecstatic epileptic seizures: a potential window on the neural basis for human self-awareness. Epilepsy Behav 16:539–546PubMedCrossRefGoogle Scholar
  92. Porges SW (2003) The polyvagal theory: phylogenetic contributions to social behavior. Physiol Behav 79:503–513PubMedCrossRefGoogle Scholar
  93. Porubska K, Veit R, Preissl H, Fritsche A, Birbaumer N (2006) Subjective feeling of appetite modulates brain activity: an fMRI study. Neuroimage 32:1273–1280PubMedCrossRefGoogle Scholar
  94. Preuschoff K, Quartz SR, Bossaerts P (2008) Human insula activation reflects risk prediction errors as well as risk. J Neurosci 28:2745–2752PubMedCrossRefGoogle Scholar
  95. Pritchard TC, Hamilton RB, Morse JR, Norgren R (1986) Projections of thalamic gustatory and lingual areas in the monkey, Macaca fascicularis. J Comp Neurol 244:213–228PubMedCrossRefGoogle Scholar
  96. Qureshy A, Kawashima R, Imran MB, Sugiura M, Goto R, Okada K, Inoue K, Itoh M, Schormann T, Zilles K, Fukuda H (2000) Functional mapping of human brain in olfactory processing: a PET study. J Neurophysiol 84:1656–1666PubMedGoogle Scholar
  97. Rosenkranz MA, Busse WW, Johnstone T, Swenson CA, Crisafi GM, Jackson MM, Bosch JA, Sheridan JF, Davidson RJ (2005) Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. Proc Natl Acad Sci USA 102:13319–13324PubMedCrossRefGoogle Scholar
  98. Roy M, Peretz I, Rainville P (2008) Emotional valence contributes to music-induced analgesia. Pain 134:140–147PubMedCrossRefGoogle Scholar
  99. Royet JP, Koenig O, Gregoire MC, Cinotti L, Lavenne F, Le BD, Costes N, Vigouroux M, Farget V, Sicard G, Holley A, Mauguiere F, Comar D, Froment JC (1999) Functional anatomy of perceptual and semantic processing for odors. J Cogn Neurosci 11:94–109PubMedCrossRefGoogle Scholar
  100. Saper CB (2002) The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annu Rev Neurosci 25:433–469PubMedCrossRefGoogle Scholar
  101. Sarinopoulos I, Dixon GE, Short SJ, Davidson RJ, Nitschke JB (2006) Brain mechanisms of expectation associated with insula and amygdala response to aversive taste: implications for placebo. Brain Behav Immunol 20:120–132CrossRefGoogle Scholar
  102. Sarinopoulos I, Grupe DW, Mackiewicz KL, Herrington JD, Lor M, Steege EE, Nitschke JB (2009) Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala. Cereb CortexGoogle Scholar
  103. Schmahmann JD, Leifer D (1992) Parietal pseudothalamic pain syndrome: clinical features and anatomic correlates. Arch Neurol 49:1032–1037PubMedGoogle Scholar
  104. Seeley WW (2010) Anterior insula degeneration in frontotemporal dementia. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0263-z
  105. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD (2007a) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27:2349–2356PubMedCrossRefGoogle Scholar
  106. Seeley WW, Allman JM, Carlin DA, Crawford RK, Macedo MN, Greicius MD, Dearmond SJ, Miller BL (2007b) Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution. Alzheimer Dis Assoc Disord 21:S50–S57PubMedCrossRefGoogle Scholar
  107. Seymour B, O’Doherty JP, Dayan P, Koltzenburg M, Jones AK, Dolan RJ, Friston KJ, Frackowiak RS (2004) Temporal difference models describe higher-order learning in humans. Nature 429:664–667PubMedCrossRefGoogle Scholar
  108. Sherrington CS (1900) Cutaneous sensations. In: Schäfer EA (ed) Text-book of physiology. Pentland, Edinburgh, pp 920–1001Google Scholar
  109. Shi CJ, Cassell MD (1998) Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices. J Comp Neurol 399:440–468PubMedCrossRefGoogle Scholar
  110. Singer W (1998) Consciousness and the structure of neuronal representations. Philos Trans R Soc Lond B Biol Sci 353:1829–1840PubMedCrossRefGoogle Scholar
  111. Singer T, Seymour B, O’Doherty J, Kaube H, Dolan RJ, Frith CD (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303:1157–1162PubMedCrossRefGoogle Scholar
  112. Small DM (2010) Taste representation in the human insula. Brain Struc Func 214(5–6). doi: 10.1007/s00429-010-0266-9
  113. Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M (2001) Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 124:1720–1733PubMedCrossRefGoogle Scholar
  114. Sommer IE, Diederen KM, Blom JD, Willems A, Kushan L, Slotema K, Boks MP, Daalman K, Hoek HW, Neggers SF, Kahn RS (2008) Auditory verbal hallucinations predominantly activate the right inferior frontal area. Brain 131:3169–3177PubMedCrossRefGoogle Scholar
  115. Spinazzola L, Pia L, Folegatti A, Marchetti C, Berti A (2008) Modular structure of awareness for sensorimotor disorders: evidence from anosognosia for hemiplegia and anosognosia for hemianaesthesia. Neuropsychologia 46:915–926PubMedCrossRefGoogle Scholar
  116. Sridharan D, Levitin DJ, Menon V (2008) A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc Natl Acad Sci USA 105:12569–12574PubMedCrossRefGoogle Scholar
  117. Stefanacci L, Amaral DG (2002) Some observations on cortical inputs to the macaque monkey amygdala: an anterograde tracing study. J Comp Neurol 451:301–323PubMedCrossRefGoogle Scholar
  118. Takahashi H, Matsuura M, Koeda M, Yahata N, Suhara T, Kato M, Okubo Y (2008) Brain activations during judgments of positive self-conscious emotion and positive basic emotion: pride and joy. Cereb Cortex 18:898–903PubMedCrossRefGoogle Scholar
  119. Taylor KS, Seminowicz DA, Davis KD (2009) Two systems of resting state connectivity between the insula and cingulate cortex. Hum Brain Mapp 30:2731–2745PubMedCrossRefGoogle Scholar
  120. Thielscher A, Pessoa L (2007) Neural correlates of perceptual choice and decision making during fear-disgust discrimination. J Neurosci 27:2908–2917PubMedCrossRefGoogle Scholar
  121. Tononi G, Koch C (2008) The neural correlates of consciousness: an update. Ann N Y Acad Sci 1124:239–261PubMedCrossRefGoogle Scholar
  122. Uddin LQ, Rayman J, Zaidel E (2005) Split-brain reveals separate but equal self-recognition in the two cerebral hemispheres. Conscious Cogn 14:633–640PubMedGoogle Scholar
  123. Uddin LQ, Supekar K, Amin H, Rykhlevskaia E, Nguyen DA, Greicius MD, Menon V (2010) Dissociable connectivity within human angular gyrus and intraparietal sulcus: evidence from functional and structural connectivity. Cereb CortexGoogle Scholar
  124. Vandenbergh J, Dupont P, Fischler B, Bormans G, Persoons P, Janssens J, Tack J (2005) Regional brain activation during proximal stomach distention in humans: a positron emission tomography study. Gastroenterology 128:564–573PubMedCrossRefGoogle Scholar
  125. Veldhuizen MG, Bender G, Constable RT, Small DM (2007) Trying to detect taste in a tasteless solution: modulation of early gustatory cortex by attention to taste. Chem Senses 32:569–581PubMedCrossRefGoogle Scholar
  126. Voets NL, Adcock JE, Flitney DE, Behrens TE, Hart Y, Stacey R, Carpenter K, Matthews PM (2006) Distinct right frontal lobe activation in language processing following left hemisphere injury. Brain 129:754–766PubMedCrossRefGoogle Scholar
  127. Vogel H, Port JD, Lenz FA, Solaiyappan M, Krauss G, Treede RD (2003) Dipole source analysis of laser-evoked subdural potentials recorded from parasylvian cortex in humans. J Neurophysiol 89:3051–3060PubMedCrossRefGoogle Scholar
  128. von Economo C (1926) Eine neue Art Spezialzellen des Lobus cinguli und Lobus insulae. Z Ges Neurol Psychiatr. 100:706–712CrossRefGoogle Scholar
  129. Wang GJ, Tomasi D, Backus W, Wang R, Telang F, Geliebter A, Korner J, Bauman A, Fowler JS, Thanos PK, Volkow ND (2008) Gastric distention activates satiety circuitry in the human brain. Neuroimage 39:1824–1831PubMedCrossRefGoogle Scholar
  130. Wegner DM (2002) The illusion of conscious will. The MIT Press, CambridgeGoogle Scholar
  131. Wheeler ME, Petersen SE, Nelson SM, Ploran EJ, Velanova K (2008) Dissociating early and late error signals in perceptual recognition. J Cogn Neurosci 20:2211–2225PubMedCrossRefGoogle Scholar
  132. Wilke M, Sohn JH, Byars AW, Holland SK (2003) Bright spots: correlations of gray matter volume with IQ in a normal pediatric population. Neuroimage 20:202–215PubMedCrossRefGoogle Scholar
  133. Winston JS, Strange BA, O’Doherty J, Dolan RJ (2002) Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nat Neurosci 5:277–283PubMedCrossRefGoogle Scholar
  134. Zautra AJ, Fasman R, Davis MC, Craig AD (2010) The effects of slow breathing on affective responses to pain stimuli: an experimental study. Pain 149:12–18PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Atkinson Research LaboratoryBarrow Neurological InstitutePhoenixUSA

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