Brain Structure and Function

, Volume 213, Issue 4–5, pp 365–366 | Cite as

Are there ten times more glia than neurons in the brain?

Brain Mythology

References

  1. Bear MF, Connors B, Paradiso M (2006) Neuroscience—exploring the brain, 3rd edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  2. Bjugn R, Gundersen HJ (1993) Estimate of the total number of neurons and glial and endothelial cells in the rat spinal cord by means of the optical dissector. J Comp Neurol 328:406–414PubMedCrossRefGoogle Scholar
  3. Christensen JR, Larsen KB, Lisanby SH, Scalia J, Arango V, Dwork AJ, Pakkenberg B (2007) Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey. Anat Rec 290:330–340CrossRefGoogle Scholar
  4. Dombrowski S, Hilgetag CC, Barbas H (2001) Quantitative architecture distinguishes prefrontal cortical systems in the rhesus monkey. Cereb Cortex 11:975–988PubMedCrossRefGoogle Scholar
  5. Herculano-Houzel S, Lent R (2005) Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J Neurosci 25:2518–2521PubMedCrossRefGoogle Scholar
  6. Herculano-Houzel S, Collins CE, Wong P, Kaas JH (2007) Cellular scaling rules for primate brains. Proc Natl Acad Sci USA 104:3562–3567PubMedCrossRefGoogle Scholar
  7. Kandel ER, Schwartz JH, Jessell TM (eds) (2000) Principles of neural science, nerve cells and behavior, 4th edn. McGraw-Hill, New York, p 22Google Scholar
  8. Lidow MS, Song ZM (2001) Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons. J Comp Neurol 435:263–275PubMedCrossRefGoogle Scholar
  9. Nedergaard M, Ransom B, Goldman SA (2003) New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 26:523–530PubMedCrossRefGoogle Scholar
  10. Noctor SC, Martínez Cerdeño V, Kriegstein AR (2007) Contribution of intermediate progenitor cells to cortical histogenesis. Arch Neurol 64:639–642PubMedCrossRefGoogle Scholar
  11. O’Kusky J, Collonnier M (1982) A laminar analysis of the number of neurons, glia, and synapses in the adult cortex (area 17) of adult macaque monkeys. J Comp Neurol 210:278–290PubMedCrossRefGoogle Scholar
  12. Pakkenberg B, Gundersen HJG (1997) Neocortical neuron number in humans: effect of sex and age. J Comp Neurol 384:312–320PubMedCrossRefGoogle Scholar
  13. Pakkenberg B, Pelvig D, Marner L, Bundgaard MJ, Gundersen HJG, Nyengaard JR, Regeur L (2003) Aging and the human neocortex. Exp Gerontol 38:95–99PubMedCrossRefGoogle Scholar
  14. Schummers J, Yu H, Sur M (2008) Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 320:1638–1643PubMedCrossRefGoogle Scholar
  15. Striedter GF (2005) Principles of brain evolution, Sinauer Associates, Inc., Sunderland, MA, USA, p 129Google Scholar
  16. West MJ (1999) Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci 22:51–61PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.School of Engineering and ScienceJacobs University BremenBremenGermany
  2. 2.Department of Health SciencesBoston UniversityBostonUSA

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