Human V5/MT+: comparison of functional and cytoarchitectonic data
To date, the delineation of the human visual “motion area” still relies on functional paradigms originally devised to identify monkey area MT. Using fMRI, we have identified putative human area V5/MT+ in normals by modelling the BOLD responses to alternating radially moving and stationary dot patterns. Functional activations were compared with cytoarchitectonic probability maps of its putative correlate area hOc5, which was calculated based upon data from histological sections of ten human post-mortem brains. Bilateral visual cortex activations were seen in the single subject dynamic versus stationary contrasts and in the group random-effects analysis. Comparison of group data with area hOc5 revealed that 19.0%/39.5% of the right/left functional activation was assigned to the right/left hOc5. Conversely, 83.2%/53.5% of the right/left hOc5 was functionally activated. Comparison of functional probability maps (fPM) with area hOc5 showed that 28.6%/18.1% of the fPM was assigned to hOc5. In turn, 84.9%/41.5% of the area hOc5 was covered by the respective fPM. Thus, random-effects data and fPMs yielded similar results. The present study shows for the first time the correspondence between the functionally defined human V5/MT+ and the post-mortem cytoarchitectonic area hOc5.
KeywordsFunctional probability map fMRI Motion Post-mortem Visual cortex
We are grateful to our colleagues from the MR and Cognitive Neurology group for their assistance. Gereon R. Fink is supported by the Deutsche Forschungsgemeinschaft (DFG KPO-112, TP1 and TP8).
- Amunts K, Malikovic A, Mohlberg H, Schormann T, Zilles K (2000) Brodman’s areas 17 and 18 brought into stereotaxic space. Where and how variable? NeuroImage 11:66–84Google Scholar
- Brett M (2002) http://www.mrc-cbu.cam.ac.uk/Imaging/Common/mnispace.shtmlGoogle Scholar
- Dupont P, Orban GA, Vogels R, Bormans G, Nuyts J, Schiepers C, De Roo M, Mortelmans L (1993) Different perceptual tasks performed with the same visual stimulus attribute activate different regions of the human brain: a positron emission tomography study. PNAS 90:10927–10931PubMedCrossRefGoogle Scholar
- Flechsig P (1927) Meine myelogenetische Hirnlehre mit biographischer Einleitung. Springer, BerlinGoogle Scholar
- Schleicher A, Amunts K, Geyer S, Morosan P, Zilles K (1999) Observer-independent method for microstructural parcellation of cerebral cortex. A quantitative approach to cytoarchitectonics. NeuroImage 9:165–177Google Scholar
- Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system—an approach to cerebral imaging. Thieme, New YorkGoogle Scholar
- Yarbus AL (1967) Eye movements and vision. Plenum Press, New YorkGoogle Scholar
- Zeki S (1993) A Vision of the Brain. Blackwell Scientific Publications, OxfordGoogle Scholar