Anatomy and Embryology

, Volume 210, Issue 5–6, pp 423–431 | Cite as

Consequences of large interindividual variability for human brain atlases: converging macroscopical imaging and microscopical neuroanatomy

  • H. B. M. Uylings
  • G. Rajkowska
  • E. Sanz-Arigita
  • K. Amunts
  • K. Zilles
Original Article

Abstract

In human brain imaging studies, it is common practice to use the Talairach stereotaxic reference system for signifying the convergence of brain function and structure. In nearly all neuroimaging reports, the studied cortical areas are specified further with a Brodmann Area (BA) number. This specification is based upon macroscopic extrapolation from Brodmann’s projection maps into the Talairach atlas rather than upon a real microscopic cytoarchitectonic study. In this review we argue that such a specification of Brodmann area(s) via the Talairach atlas is not appropriate. Cytoarchitectonic studies reviewed in this paper show large interindividual differences in 3-D location of primary sensory cortical areas (visual cortex) as well as heteromodal associational areas (prefrontal cortical areas), even after correction for differences in brain size and shape. Thus, the simple use of Brodmann cortical areas derived from the Talairach atlas can lead to erroneous results in the specification of pertinent BA. This in turn can further lead to wrong hypotheses on brain system(s) involved in normal functions or in specific brain disorders. In addition, we will briefly discuss the different ‘Brodmann’ nomenclatures which are in use for the cerebral cortex.

Keywords

Brain mapping Cerebral cortex Sulcal pattern Brodmann areas Cytoarchitectonics 

Notes

Acknowledgments

We would like to thank Mrs. W.T.P. Verweij for secretarial assistance and Mr. G. Van der Meulen for photography. The different studies on which this short review is based were supported by various grants: NATO grant CRG 9671225 (HBMU, GR), by NIH grants# MH 55872 and MH61578 (GR), by grant of Hersenstichting Ned. (HBMU, ES) and by grant of RIKEN, Japan (HBMU,ES) and by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health (KZ, KA).

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • H. B. M. Uylings
    • 1
    • 2
  • G. Rajkowska
    • 3
  • E. Sanz-Arigita
    • 1
  • K. Amunts
    • 4
    • 5
  • K. Zilles
    • 4
    • 6
  1. 1.Netherlands Institute for Brain ResearchGraduate School Neurosciences Amsterdam, Royal Netherlands Academy of Arts and SciencesAmsterdamThe Netherlands
  2. 2.Department of Anatomy, VU University Medical CenterGraduate School Neurosciences AmsterdamAmsterdamThe Netherlands
  3. 3.Department of Psychiatry and Department of AnatomyUniversity of Mississippi Medical CenterJacksonUSA
  4. 4.Institute of MedicineResearch Center JülichJülichGermany
  5. 5.Department of Psychiatry and PsychotherapyRWTH Aachen UniversityAachenGermany
  6. 6.C. and O. Vogt Institute for Brain ResearchUniversity of DüsseldorfDüsseldorfGermany

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