Anatomy and Embryology

, Volume 210, Issue 5–6, pp 519–523

Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia

  • René Hurlemann
  • Christian Boy
  • Philipp T. Meyer
  • Harald Scherk
  • Michael Wagner
  • Hans Herzog
  • Heinz H. Coenen
  • Kai Vogeley
  • Peter Falkai
  • Karl Zilles
  • Wolfgang Maier
  • Andreas Bauer
Original Article

Abstract

The brain serotonin-2A receptor (5-HT2AR) has been implicated in both the pathology of schizophrenia and the therapeutic action of atypical antipsychotics. However, little is known about the 5-HT2AR status before the onset of schizophrenia and before the exposure to antipsychotics. We used [18F] altanserin and positron emission tomography (PET) in a pilot study of 6 individuals suspected to be at elevated risk for schizophrenia and seven age-matched controls to test the hypothesis that regional 5-HT2AR binding is altered in the prodromal stages of schizophrenia. Distribution volume ratios (DVRs) as a proxy for 5-HT2AR availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities of serotonergic neurotransmission that antecede the onset of schizophrenia.

Keywords

Serotonin-2A [(18)F]Altanserin PET At-risk Psychosis Schizophrenia 

Abbreviations

DVR

distribution volume ratio

ROI

region of interest

at-risk

subjects with prodromal states for schizophrenia

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • René Hurlemann
    • 1
    • 2
  • Christian Boy
    • 2
  • Philipp T. Meyer
    • 2
  • Harald Scherk
    • 1
    • 4
  • Michael Wagner
    • 1
  • Hans Herzog
    • 2
  • Heinz H. Coenen
    • 3
  • Kai Vogeley
    • 1
    • 2
  • Peter Falkai
    • 1
    • 4
  • Karl Zilles
    • 2
    • 5
  • Wolfgang Maier
    • 1
  • Andreas Bauer
    • 2
  1. 1.Department of PsychiatryUniversity of BonnBonnGermany
  2. 2.Brain Imaging Center West, Institute of MedicineResearch Center JülichJülichGermany
  3. 3.Institute of Nuclear ChemistryResearch Center JülichJülichGermany
  4. 4.Department of PsychiatrySaarland University HospitalHomburg/SaarGermany
  5. 5.C. & O. Vogt Institute for Brain ResearchUniversity of DuesseldorfDuesseldorfGermany

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