Virchows Archiv

, Volume 434, Issue 2, pp 117–120

In serous ovarian neoplasms the frequency of Ki-ras mutations correlates with their malignant potential

  • C. J. Haas
  • Joachim Diebold
  • Astrid Hirschmann
  • Helmut Rohrbach
  • Udo Löhrs
ORIGINAL ARTICLE

Ki-ras

mutations by denaturing gradient gel electrophoresis (DGGE) and direct sequencing after microdissection. Point mutations at codon 12 were found in 7 of 20 tumours of low malignant potential (LMP) (35%) and in 2 of 6 well-differentiated carcinomas (33%). In contrast, no mutations were detected in the 11 poorly differentiated ovarian carcinoma samples or in the 7 serous cystadenomas. The frequency of Ki-ras mutations in serous ovarian tumours seems to correlate with the malignant potential of the neoplasms. The data favour the hypothesis of a de novo development of poorly differentiated ovarian carcinomas and do not support an evolution from LMP tumours or well-differentiated carcinomas.

Key words Ki-ras mutations Serous ovarian neoplasms DGGE LMP tumours Carcinomas Cystadenomas 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • C. J. Haas
    • 1
  • Joachim Diebold
    • 1
  • Astrid Hirschmann
    • 1
  • Helmut Rohrbach
    • 1
  • Udo Löhrs
    • 1
  1. 1.Institute of Pathology, Ludwig-Maximilians-Universität, Munich, GermanyDE

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