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Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions

  • Tadakazu Ao
  • Yoshiki KajiwaraEmail author
  • Keisuke Yonemura
  • Eiji Shinto
  • Satsuki Mochizuki
  • Koichi Okamoto
  • Yoji Kishi
  • Hideki Ueno
Original Article
  • 25 Downloads

Abstract

Some preceding studies show that a desmoplastic reaction (DR) at the invasive front of a primary tumor (DRprimary) is a promising prognostic indicator, and its histologic classification is an independent prognostic factor in patients with colorectal cancer (CRC). Although DR is observed in metastatic lesions, such as those in lymph nodes (DRLN) and the liver (DRliver), the association between DRprimary and DR of metastatic lesions is unclear. We investigated whether DRLN and DRliver could be categorized in the same manner as DRprimary and examined the features and prognostic implications of DRLN and DRliver. In this study, we evaluated 363 patients with metastases to lymph nodes and 45 patients with synchronous liver metastases who underwent curative resection. DRLN and DRliver statuses were classified as mature, intermediate, or immature, based on keloid-like collagen and myxoid stroma appearances in the metastatic lesions. Overall, 109, 106, and 148 patients had mature, intermediate, and immature DRLN, respectively; in total, 5, 21, and 19 patients had mature, intermediate, and immature DRliver, respectively. DRLN and DRprimary (spearman’s rho = 0.43, P < 0.0001) and DRliver and DRprimary (spearman’s rho = 0.40, P = 0.0069) were each significantly correlated. The 5-year relapse-free survival (RFS) after surgery was 67.7% for mature/intermediate DRLN and 52.9% for immature DRLN; the 5-year RFS after hepatectomy was 11.5% for mature/intermediate DRliver and 5.6% for immature DRliver. In conclusion, DRLN and DRliver may be classified in the same manner as DRprimary; morphological consistency of DR was observed between primary and metastatic lesions.

Keywords

Desmoplastic reaction Colorectal cancer Lymphatic metastases Liver metastases Cancer-associated fibroblasts 

Abbreviations

CAF

Cancer-associated fibroblast

CRC

Colorectal cancer

DR

Desmoplastic reaction

DRLN

Desmoplastic reaction in the lymph node metastases

DRliver

Desmoplastic reaction in the colorectal liver metastases

DRprimary

Desmoplastic reaction in the primary tumor

OS

Overall survival

RFS

Relapse-free survival

MLN

Metastatic lymph nodes

Notes

Acknowledgments

The authors would like to thank Dr. Hideyuki Shimazaki from the Department of Laboratory Medicine, National Defense Medical College for providing pathological evaluation.

Author contribution

Tadakazu Ao and Yoshiki Kajiwara conceived and designed the study, and wrote, edited, and reviewed the manuscript. Keisuke Yonemura collected the data and reviewed the manuscript. Eiji Shinto, Satsuki Mochizuki, Koichi Okamoto, and Yoji Kishi revised the manuscript. Hideki Ueno conceived and designed the study, and reviewed manuscript. All authors approved the final version of the manuscript for publication. Tadakazu Ao takes full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript.

Compliance with ethical standards

Ethical approval

The experiments reported here were conducted in agreement with the Declaration of Helsinki, and were approved by the Ethics Committee of the National Defense Medical College Hospital (Tokorozawa, Japan).

Conflicts of interest

The authors declare that they have no conflict of interest.

Supplementary material

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ESM 1

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High Resolution Image (TIF 116 kb)
428_2019_2742_MOESM2_ESM.docx (25 kb)
ESM 2 (DOCX 24 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of SurgeryNational Defense Medical CollegeSaitamaJapan

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