Virchows Archiv

, Volume 475, Issue 5, pp 535–536 | Cite as

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Stolnica et al. ( open this issue with a review on the classification of endocervical adenocarcinomas. Insufficient impact of the 2014 World Health Organization classification led to the development of a new approach known as the International Endocervical Adenocarcinoma Criteria and Classification. The innovative element in this classification is its distinction between human papillomavirus (HPV)-associated and non–HPV-associated endocervical adenocarcinomas, based on morphological criteria only without the need for immunohistochemical markers. Clinical and demographic characteristics appear to support this dichotomy. The clinical importance of the host of morphological subtypes in each of these two categories is less clear, as many are quite rare and large studies on their clinicopathological characteristics might not have been conducted as yet. The authors foresee better potential for precision medicine approaches using the new...


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

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