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Virchows Archiv

, Volume 475, Issue 5, pp 659–663 | Cite as

Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma

  • Yasuhiko Mizuguchi
  • Taku Sakamoto
  • Taiki Hashimoto
  • Shunsuke Tsukamoto
  • Satoru Iwasa
  • Yutaka Saito
  • Shigeki SekineEmail author
Brief Report
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Abstract

Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal serrated lesion. We here report a sigmoid colon cancer derived from SuSA, which exhibited aggressive clinical behavior. Endoscopically, the tumor appeared as a superficial elevated lesion with a large nodule. Histological examination of the surgically resected material showed tubular adenocarcinoma associated with SuSA. Although tumor invasion was limited to the submucosal layer, lymph node and extranodal metastases were detected. The patient subsequently developed peritoneal metastases and died 15 months after surgery. Molecular analyses identified a KRAS mutation and a novel PRR15L-RSPO2 fusion, which retains the entire coding region of RSPO2, in both SuSA and adenocarcinoma components. The present study demonstrates the malignant potential of SuSA and expands the spectrum of RSPO fusions in colorectal neoplasms.

Keywords

Colorectal cancer R-spondin Superficially serrated adenoma KRAS 

Notes

Acknowledgments

We thank Ms. Reiko Ogawa, Ms. Sachiko Miura, and Ms. Toshiko Sakaguchi for their skillful technical assistance.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Endoscopy DivisionNational Cancer Center HospitalTokyoJapan
  2. 2.Division of Pathology and Clinical LaboratoriesNational Cancer Center HospitalTokyoJapan
  3. 3.Division of Colorectal SurgeryNational Cancer Center HospitalTokyoJapan
  4. 4.Division of Gastrointestinal Medical OncologyNational Cancer Center HospitalTokyoJapan
  5. 5.Division of Molecular PathologyNational Cancer Center Research InstituteTokyoJapan

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