A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach

  • Rin YamadaEmail author
  • Shin-ichiro Horiguchi
  • Ryoko Shimizuguchi
  • Natsuko Nakano
  • Toru Motoi
  • Kumiko Monma
  • Tsunekazu Hishima
Brief Report


Primary gastric squamous cell carcinoma (SCC) is a rare histological subtype of gastric cancer. Here, we report the first case of primary gastric verrucous carcinoma (VC), a well-differentiated variant of SCC. Gastroscopy revealed a papillary polypoid lesion at the posterior wall of the upper gastric body and isolated squamous epithelium at the greater curvature of the fornix in a 78-year-old woman. Endoscopic submucosal dissection was performed. Microscopically, the lesion comprised very well-differentiated squamous epithelium with minimal atypia and exhibited coarse papillary structure and bulbous epithelial downgrowth with submucosal invasion. Conventional SCC or adenocarcinoma components were not included, and the lesion was surrounded by the metaplastic intestinal mucosa. Human papillomavirus infection was not detected. Although the pathogenesis of primary gastric SCC remains controversial, here, the disease is suggested as having originated from squamous epithelium. Knowledge of primary gastric VC and difficulty in diagnosing it using surface biopsy is necessary.


Gastric cancer Squamous cell carcinoma Verrucous carcinoma Squamous metaplasia 



We would like to thank the pathologists who attended the 80th meeting of The Japanese Society of Pathology Kanto for making us part of a useful discussion.

Authors’ contributions

RY drafted the manuscript. RS and KM provided clinical details. SH, NN, TM, and TH evaluated the histological findings. SH edited and reviewed the manuscript. All authors gave final approval for publication.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from the patient included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PathologyTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan
  2. 2.Department of EndoscopyTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan

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