Advertisement

ALK-negative anaplastic large cell lymphoma arising in the thrombus of an aortic prosthesis preceeded by clonally related lymphomatoid papulosis

  • Thomas Menter
  • Veronika Ballova
  • Clemens Caspar
  • Thomas Wolff
  • Benjamin Kasenda
  • Gad Singer
  • Darius Juskevicius
  • Alexandar Tzankov
  • Stefan DirnhoferEmail author
Brief Communication

Abstract

We report on a 73-year-old male patient with recurrent thrombosis of his infrarenal aortic prosthesis. Histologically, the thrombus contained cells of an ALK-negative anaplastic large cell T cell lymphoma (ALCL). Imaging studies were negative for other lymphoma manifestations; however, 3 months before, the patient had developed skin lesions consistent with lymphomatoid papulosis type A (LypA) which were clonally related to the ALCL. Due to recurrent thrombosis of larger peripheral arteries with the presence of ALCL cells in the thrombi, the patient is now referred to systemic chemotherapy. We present the first case of ALCL manifesting in the thrombus of an aortic prosthesis. This case shows similarities to the well-established entity of breast implant-associated ALCL and anecdotal reports of ALCL occurring at the site of foreign material implants. These cells show a peculiar propensity to aggregate in vessels and thrombi, known primarily from subtypes of diffuse large B cell lymphomas associated with chronic inflammation.

Keywords

Anaplastic large cell lymphoma Lymphomatoid papulosis PTFE Aortic prosthesis Breast implant-associated ALCL 

Notes

Acknowledgements

We thank Dr. Charlotte K Y Ng for critically reading the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

References

  1. 1.
    Swerdlow S, Campo E, Harris N et al (2017) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, LyonGoogle Scholar
  2. 2.
    Meier VS, Rufle A, Gudat F (2001) Simultaneous evaluation of T- and B-cell clonality, t(11;14) and t(14;18), in a single reaction by a four-color multiplex polymerase chain reaction assay and automated high-resolution fragment analysis: a method for the rapid molecular diagnosis of lymphoproliferative disorders applicable to fresh frozen and formalin-fixed, paraffin-embedded tissues, blood, and bone marrow aspirates. Am J Pathol 159:2031–2043CrossRefGoogle Scholar
  3. 3.
    Juskevicius D, Lorber T, Gsponer J, Perrina V, Ruiz C, Stenner-Liewen F, Dirnhofer S, Tzankov A (2016) Distinct genetic evolution patterns of relapsing diffuse large B-cell lymphoma revealed by genome-wide copy number aberration and targeted sequencing analysis. Leukemia 30:2385–2395CrossRefGoogle Scholar
  4. 4.
    Menter T, Juskevicius D, Alikian M, Steiger J, Dirnhofer S, Tzankov A, Naresh KN (2017) Mutational landscape of B-cell post-transplant lymphoproliferative disorders. Br J Haematol 178:48–56CrossRefGoogle Scholar
  5. 5.
    Campanale A, Boldrini R, Marletta M (2018) 22 cases of breast implant-associated ALCL: awareness and outcome tracking from the Italian Ministry of Health. Plast Reconstr Surg 141:11e–19eCrossRefGoogle Scholar
  6. 6.
    Palraj B, Paturi A, Stone RG, Alvarez H, Sebenik M, Perez MT, Bush LM (2010) Soft tissue anaplastic large T-cell lymphoma associated with a metallic orthopedic implant: case report and review of the current literature. J Foot Ankle Surg 49:561–564CrossRefGoogle Scholar
  7. 7.
    Manikkam Umakanthan J, McBride CL, Greiner T et al (2017) Bariatric implant-associated anaplastic large-cell lymphoma. J Oncol Pract 13:838–839CrossRefGoogle Scholar
  8. 8.
    Zacchi F, Castelli J, Stiepcich M et al (2018) Gluteal-implant associated anaplastic large cell lymphoma: a case report and proposal for a new terminology. EAHP, EdinburghGoogle Scholar
  9. 9.
    Ozkaya N, Grogg KL, Dogan A (2016) Seroma-associated anaplastic large-cell lymphoma arising on the background of subcutaneous calcinosis: beyond breast implants. Histopathology 69:890–892CrossRefGoogle Scholar
  10. 10.
    Hu H, Jacombs A, Vickery K, Merten SL, Pennington DG, Deva AK (2015) Chronic biofilm infection in breast implants is associated with an increased T-cell lymphocytic infiltrate: implications for breast implant-associated lymphoma. Plast Reconstr Surg 135:319–329CrossRefGoogle Scholar
  11. 11.
    Kadin ME, Deva A, Xu H, Morgan J, Khare P, MacLeod RAF, van Natta BW, Adams WP Jr, Brody GS, Epstein AL (2016) Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma. Aesthet Surg J 36:773–781CrossRefGoogle Scholar
  12. 12.
    Bizjak M, Selmi C, Praprotnik S, Bruck O, Perricone C, Ehrenfeld M, Shoenfeld Y (2015) Silicone implants and lymphoma: the role of inflammation. J Autoimmun 65:64–73CrossRefGoogle Scholar
  13. 13.
    Menger MD, Hammersen F, Messmer K (1992) In vivo assessment of neovascularization and incorporation of prosthetic vascular biografts. Thorac Cardiovasc Surg 40:19–25CrossRefGoogle Scholar
  14. 14.
    Laurent C, Haioun C, Brousset P, Gaulard P (2018) New insights into breast implant-associated anaplastic large cell lymphoma. Curr Opin Oncol 30:292–300Google Scholar
  15. 15.
    Boyer DF, McKelvie PA, de Leval L et al (2017) Fibrin-associated EBV-positive large B-cell lymphoma: an indolent neoplasm with features distinct from diffuse large B-cell lymphoma associated with chronic inflammation. Am J Surg Pathol 41:299–312CrossRefGoogle Scholar
  16. 16.
    de Souza A, el-Azhary RA, Camilleri MJ, Wada DA, Appert DL, Gibson LE (2012) In search of prognostic indicators for lymphomatoid papulosis: a retrospective study of 123 patients. J Am Acad Dermatol 66:928–937CrossRefGoogle Scholar
  17. 17.
    Aladily TN, Medeiros LJ, Amin MB, Haideri N, Ye D, Azevedo SJ, Jorgensen JL, de Peralta-Venturina M, Mustafa EB, Young KH, You MJ, Fayad LE, Blenc AM, Miranda RN (2012) Anaplastic large cell lymphoma associated with breast implants: a report of 13 cases. Am J Surg Pathol 36:1000–1008CrossRefGoogle Scholar
  18. 18.
    Wieser I, Oh CW, Talpur R, Duvic M (2016) Lymphomatoid papulosis: treatment response and associated lymphomas in a study of 180 patients. J Am Acad Dermatol 74:59–67CrossRefGoogle Scholar
  19. 19.
    Crescenzo R, Abate F, Lasorsa E, Tabbo' F, Gaudiano M, Chiesa N, di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarra E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Ponzoni M, Paulli M, Weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo' A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G, European T-Cell Lymphoma Study Group, T-Cell Project: Prospective Collection of Data in Patients with Peripheral T-Cell Lymphoma and the AIRC 5xMille Consortium “Genetics-Driven Targeted Management of Lymphoid Malignancies” (2015) Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell 27:516–532CrossRefGoogle Scholar
  20. 20.
    Bruns HA, Kaplan MH (2006) The role of constitutively active Stat6 in leukemia and lymphoma. Crit Rev Oncol Hematol 57:245–253CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Thomas Menter
    • 1
  • Veronika Ballova
    • 2
  • Clemens Caspar
    • 2
  • Thomas Wolff
    • 3
  • Benjamin Kasenda
    • 4
  • Gad Singer
    • 5
  • Darius Juskevicius
    • 1
  • Alexandar Tzankov
    • 1
  • Stefan Dirnhofer
    • 1
    Email author
  1. 1.Institute of Pathology and Medical GeneticsUniversity Hospital BaselBaselSwitzerland
  2. 2.Department of Medical OncologyCantonal Hospital BadenBadenSwitzerland
  3. 3.Department of Vascular SurgeryUniversity Hospital BaselBaselSwitzerland
  4. 4.Department of Medical OncologyUniversity Hospital BaselBaselSwitzerland
  5. 5.Institute of PathologyCantonal Hospital BadenBadenSwitzerland

Personalised recommendations