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CIC fusion-positive sarcoma of the spermatic cord

  • Felix Bremmer
  • Alexander Fichtner
  • Ralph Triefenbach
  • Reinhard Inniger
  • Peter Mayer
  • Laura Lukat
  • Philipp Ströbel
  • Hans Ulrich Schildhaus
Brief Report

Abstract

In addition to germ cell tumors and tumors of the sex cord stroma, the WHO classification of testis and paratesticular tumors also contains malignant soft tissue tumors. Among them, liposarcomas of the spermatic cord are the most common entities. Other mesenchymal tumors with smooth muscle, skeletal muscle, fibroblastic/myofibroblastic, or nerve sheath differentiation are rare. Ewing sarcoma is composed of uniform small round cells and typically characterized by translocations of the EWSR1 gene. In rare cases, Ewing sarcoma-like tumors lack an EWSR1 gene fusion. Some of these tumors harbor a specific CIC translocation. However, Ewing-like sarcoma has up to now never been described in the testis or spermatic cord. The present case describes the first EWSR1-negative, undifferentiated round cell sarcoma with CIC translocation of the spermatic cord. Potential differential diagnoses are discussed.

Keywords

CIC translocation Spermatic cord Testis Ewing-like sarcoma 

Notes

Author contributions

F.B. A.F., and P.S. were responsible design of the study, interpretation of the results, and writing the manuscript. L.L. and H.U.S. were responsible for FISH experiments. R.T., A.F., R.I. and F.B. contributed critical discussion of the experiments and results. F.B., A.F., P.S., and H.U.S. reviewed the manuscript.

Funding

FB is supported by the Wilhelm-Sander-Stiftung (2016.041.1).

Compliance with ethical standards

The case report was approved by the ethics committee of the University Medical Center Göttingen (applicant number: 7/2/18An). The patient gave his formal consent to the publication of the data.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Felix Bremmer
    • 1
  • Alexander Fichtner
    • 1
  • Ralph Triefenbach
    • 2
  • Reinhard Inniger
    • 2
  • Peter Mayer
    • 3
  • Laura Lukat
    • 1
  • Philipp Ströbel
    • 1
  • Hans Ulrich Schildhaus
    • 1
  1. 1.Institute of PathologyUniversity Medical Center GöttingenGöttingenGermany
  2. 2.Center for Pathology, Cytology and Molecular PathologyDüsseldorfGermany
  3. 3.Department of UrologyCatholic Clinics OberbergEngelskirchenGermany

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