Primary classic Hodgkin lymphoma of the ileum and Epstein-Barr virus mucocutaneous ulcer of the colon: two entities compared
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Primary classic Hodgkin lymphoma of the gastrointestinal tract represents a rare occurrence. A full patient’s work-up is essential in order to exclude a secondary intestinal involvement. Histologically Epstein-Barr virus mucocutaneous ulcer closely resembles Hodgkin lymphoma. The differential diagnosis between these two entities is relevant, since both the therapeutic approach and the clinical behavior are different. Herein, we describe a case of primary classic Hodgkin lymphoma arising in the ileum and a case of Epstein-Barr virus mucocutaneous ulcer of the colon, focusing on the main clinicopathological differences.
KeywordsHodgkin lymphoma Epstein-Barr virus Mucocutaneous Ulcer Diverticulitis
We would like to particularly thank Professor Elaine Jaffe for her important observations in the drafting of the paper.
MZ made the diagnosis of EBVRMCU and wrote the paper; MCM is the corresponding author and collected the medical history of the patients; RV reviewed the literature data and contributed to the discussion; EF took the photos and made the immunohistochemical analysis of the case of EBVRMCU; AB made the molecular investigations; MZ performed the surgical resections; LDM reviewed the literature data and contributed to the discussion; SA made the diagnosis of LH, took the photos, and made the immunohistochemical analysis of the case of LH. All the authors have reviewed and approved the final version of the manuscript.
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Conflict of interest
The authors declare that they have no conflict of interest.
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