Virchows Archiv

, Volume 474, Issue 1, pp 117–123 | Cite as

Primary classic Hodgkin lymphoma of the ileum and Epstein-Barr virus mucocutaneous ulcer of the colon: two entities compared

  • Magda Zanelli
  • Maria Cecilia Mengoli
  • Riccardo Valli
  • Elisabetta Froio
  • Alessandra Bisagni
  • Maurizio Zizzo
  • Loredana De Marco
  • Stefano Ascani
Brief Report


Primary classic Hodgkin lymphoma of the gastrointestinal tract represents a rare occurrence. A full patient’s work-up is essential in order to exclude a secondary intestinal involvement. Histologically Epstein-Barr virus mucocutaneous ulcer closely resembles Hodgkin lymphoma. The differential diagnosis between these two entities is relevant, since both the therapeutic approach and the clinical behavior are different. Herein, we describe a case of primary classic Hodgkin lymphoma arising in the ileum and a case of Epstein-Barr virus mucocutaneous ulcer of the colon, focusing on the main clinicopathological differences.


Hodgkin lymphoma Epstein-Barr virus Mucocutaneous Ulcer Diverticulitis 



We would like to particularly thank Professor Elaine Jaffe for her important observations in the drafting of the paper.

Author contributions

MZ made the diagnosis of EBVRMCU and wrote the paper; MCM is the corresponding author and collected the medical history of the patients; RV reviewed the literature data and contributed to the discussion; EF took the photos and made the immunohistochemical analysis of the case of EBVRMCU; AB made the molecular investigations; MZ performed the surgical resections; LDM reviewed the literature data and contributed to the discussion; SA made the diagnosis of LH, took the photos, and made the immunohistochemical analysis of the case of LH. All the authors have reviewed and approved the final version of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pathology Unit, Azienda Unità Sanitaria Locale/IRCCSReggio EmiliaItaly
  2. 2.Department of Oncology and Advanced Technologies, Surgical Oncology UnitAzienda Unità Sanitaria Locale/IRCCSReggio EmiliaItaly
  3. 3.Clinical and Experimental Medicine PhD ProgramUniversity of Modena and Reggio EmiliaModenaItaly
  4. 4.Pathology Unit, Ospedale di TerniUniversity of PerugiaPerugiaItaly

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