Virchows Archiv

, Volume 473, Issue 1, pp 127–130 | Cite as

Non-sebaceous lymphadenoma of the lacrimal gland: first report of a new localization

  • Mauro Pau
  • Luka BrcicEmail author
  • Raja R. Seethala
  • Angelika K. Klein-Theyer
  • Marton Magyar
  • Knut E. Reinbacher
  • Michael Schweiger
  • Jürgen Wallner
  • Norbert Jakse
Brief Report


Tumors of the lacrimal gland are rare, with an incidence of less than 1 per 1,000,000 individuals per year [1]. They represent 6–12% of all orbital space-occupying lesions. Approximately 22–28% of these are primary epithelial tumors [2, 3, 4].

Since lacrimal gland tumors generally recapitulate the clinicopathologic features of their salivary gland counterparts, the World Health Organization (WHO) classification of salivary gland tumors can be applied to these tumors as well [5].

Fifty percent of primary epithelial tumors of the lacrimal gland are malignant. The most frequently encountered type is adenoid cystic carcinoma, which comprises approximately 20–30% of malignant neoplasms [6]. However, a variety of malignant tumor types that mirror their salivary gland counterparts have been described including ductal carcinoma, acinic cell carcinoma, primary squamous cell carcinoma, mucoepidermoid carcinoma, oncocytic carcinoma, polymorphous low-grade adenocarcinoma, carcinoma...


Compliance with ethical standards

This manuscript is a report of a case with a review of the literature. Research work with human and animal subjects was not conducted in preparation of this manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    von Holstein SL, Therkildsen MH, Prause JU, Stenman G, Siersma VD, Heegaard S (2013) Lacrimal gland lesions in Denmark between 1974 and 2007. Acta Ophthalmol 91:349–354CrossRefGoogle Scholar
  2. 2.
    Kennedy RE (1984) An evaluation of 820 orbital cases. Trans Am Ophthalmol Soc 82:134–157PubMedPubMedCentralGoogle Scholar
  3. 3.
    Shields CL, Shields JA, Eagle RC, Rathmell JP (1989) Clinicopathologic review of 142 cases of lacrimal gland lesions. Ophthalmology 96:431–435CrossRefPubMedGoogle Scholar
  4. 4.
    Johansen S, Heegaard S, Bogeskov L, Prause JU (2000) Orbital space-occupying lesions in Denmark 1974–1997. Acta Ophthalmol Scand 78:547–552CrossRefPubMedGoogle Scholar
  5. 5.
    (2017) Tumours of salivary glands In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (eds) WHO classification of head and neck tumours, 4th edn. IARC, Lyon, pp 159–201Google Scholar
  6. 6.
    von Holstein SL, Coupland SE, Briscoe D, Le Tourneau C, Heegaard S (2013) Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey. Acta Ophthalmol 91:195–206CrossRefGoogle Scholar
  7. 7.
    Font RL, Croxatto JO, Rao NA (2006) Tumours of the lacrimal gland. In: Silverberg SG (ed) Tumours of the eye and ocular adnexa, 4th edn. American Registry of Pathology / Armed Forces Institute of Pathology, Washington DC, pp 223–246Google Scholar
  8. 8.
    Liu G, He J, Zhang C, Fu S, He Y (2014) Lymphadenoma of the salivary gland: report of 10 cases. Oncol Lett 7:1097–1101CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    (2017) Tumours of salivary glands. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (eds) WHO classification of head and neck tumours, 4th edn. IARC, Lyon, pp 190–191Google Scholar
  10. 10.
    Yang S, Chen X, Wang L, Zhang J (2007) Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation. Virchows Arch 450:595–599CrossRefPubMedGoogle Scholar
  11. 11.
    Gallego L, Junquera L, Fresno MF (2009) Non-sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:555–558CrossRefPubMedGoogle Scholar
  12. 12.
    Seethala RR, Thompson LDR, Gnepp DR, Barnes EL, Skalova A, Montone K, Kane S, Lewis JS Jr, Solomon LW, Simpson RHW, Khan A, Prasad ML (2012) Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol 25:26–35CrossRefPubMedGoogle Scholar
  13. 13.
    Weiler C, Agaimy A, Zengel P, Zenk J, Kirchner T, Ihrler S (2012) Nonsebaceous lymphadenoma of salivary glands: proposed development from intraparotid lymph nodes and risk of misdiagnosis. Virchows Arch 460:467–472CrossRefPubMedGoogle Scholar
  14. 14.
    Weis E, Rootman J, Joly TJ, Berean KW, Al-Katan HM, Pasternak S, Bonavolontà G, Strianese D, Saeed P, Feldman KA, Vangveeravong S, Lapointe JS, White VA (2009) Epithelial lacrimal gland tumors pathologic classification and current understanding. Arch Ophthalmol 127:1016–1028CrossRefPubMedGoogle Scholar
  15. 15.
    Musthyala NB, Low SE, Seneviratne RH (2009) Lymphadenoma of the salivary gland: a rare tumour. J Clin Pathol 57:1007CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Mauro Pau
    • 1
  • Luka Brcic
    • 2
    Email author
  • Raja R. Seethala
    • 3
  • Angelika K. Klein-Theyer
    • 4
  • Marton Magyar
    • 5
  • Knut E. Reinbacher
    • 1
  • Michael Schweiger
    • 1
  • Jürgen Wallner
    • 1
  • Norbert Jakse
    • 1
  1. 1.Department of Oral and Maxillofacial SurgeryMedical University of GrazGrazAustria
  2. 2.Institute of PathologyMedical University of GrazGrazAustria
  3. 3.Department of PathologyUniversity of Pittsburgh Medical CenterPittsburghUSA
  4. 4.Department of OphthalmologyMedical University of GrazGrazAustria
  5. 5.Department of RadiologyMedical University of GrazGrazAustria

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