Virchows Archiv

, Volume 471, Issue 6, pp 753–759 | Cite as

Prostate cancer in Jordanian-Arab population: ERG status and relationship with clinicopathologic characteristics

  • Najla Aldaoud
  • Nour Abdo
  • Samir Al Bashir
  • Mohammad Alqudah
  • Noor Marji
  • Hiba Alzou’bi
  • Rami Alazab
  • Kiril Trpkov
Original Article


TMPRSS2/ERG fusion was found to be the most common genetic event in prostate adenocarcinoma. There is a strong correlation between the fusion and ERG-positive immunostaining. Many studies showed racial variation in ERG expression in prostate cancer patients. There is no data however on the rate of ERG-positive cancer in Jordanian or Arab population. We evaluated the frequency and the significance of ERG fusion in Jordanian-Arab population using immunohistochemistry for ERG. The cohort included 193 prostate cancer specimens: 109 needle core biopsies, 45 radical prostatectomies, 37 transurethral resections of prostate, and 2 enucleation specimens. We found ERG reactivity in 64 (33.2%) of evaluated cases. The observed ERG frequency in the Jordanian-Arab population is lower than the one documented in North America, but it is higher than in Asian patient cohorts. The ERG positivity was significantly associated with lower baseline prostate-specific antigen but was unrelated to patient age, Gleason Score, or the novel Gleason Grade Groups. In the 45 prostatectomy cases, ERG did not correlate with the pathologic stage, margin, nodal status, and the biochemical recurrence, and it did not appear to represent an important prognosticator.


Prostate cancer Jordan Immunohistochemistry TMPRSS2: ERG 


Compliance with ethical standards

This study was approved by the Institutional Review Board of Jordan University of Science and Technology.

Conflict of interest

The authors declare that they have no conflict of interest.


This research was funded by the grant from the Deanship of Research, Jordan University of Science and Technology, Irbid, Jordan.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Pathology and MicrobiologyJordan University of Science and TechnologyIrbidJordan
  2. 2.Department of Pathology King Abdullah University hospitalJordan University of Science and TechnologyIrbidJordan
  3. 3.Department of Public HealthJordan University of Science and TechnologyIrbidJordan
  4. 4.Department of PathologyYarmouk UniversityIrbidJordan
  5. 5.Department of UrologyJordan University of Science and TechnologyIrbidJordan
  6. 6.Department of Pathology and Laboratory MedicineUniversity of CalgaryCalgaryCanada

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