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PLAG1 expression is maintained in recurrent pleomorphic adenoma

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Abstract

The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pleomorphic adenoma (PA). Its expression in recurrent pleomorphic adenoma (RPA), however, has not been investigated. Since complex mechanisms are involved in tumor recurrence, the aim of this study was to investigate whether PLAG1 overexpression occurs in RPA. We studied PLAG1 protein expression in 40 PAs and 36 RPAs by immunohistochemistry. Cases with immunopositive cells were classified into two categories, between 10 and 50 % and >50 %. In both groups, PLAG1 expression was observed in both epithelial and myoepithelial cells. Of PAs, 37 cases (93 %) were positive, while this was the case in 34 RPA cases (94 %). Our findings suggest that in addition to morphological similarity, PA and RPA express PLAG1, which might play a role in tumor recurrence. Furthermore, as for PA, expression of PLAG1 can be considered a valuable diagnostic marker for RPA.

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Acknowledgment

The authors would like to thank Ana Cláudia Sparapani Piazza, Arethusa Souza, Fabiana Faco Casarotti, and Luzia Magalhães Alves for technical assistance.

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Authors and Affiliations

  1. Pathology Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil

    Beatriz Samara de Brito, Natália Giovanelli Gaspar, Erika Said Abu Egal, Albina Altemani & Fernanda Viviane Mariano

  2. Oral Pathology Department, Piracicaba Dental School, State University of Campinas (UNICAMP), Campinas, SP, Brazil

    Celeste Sanchez-Romero & Oslei Paes de Almeida

  3. Head and Neck Surgery Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil

    Antonio Santos Martins & Álfio José Tincani

  4. Pathology Department, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil

    Rogério de Oliveira Gondak

  5. Head and Neck Surgery Department, AC Camargo Cancer Center, São Paulo, SP, Brazil

    Luiz Paulo Kowalski

  6. Departamento de Anatomia Patológica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Av. Tessália Vieira de Camargo, 126 – Barão Geraldo, Cidade Universitária, Campinas, SP, 13083-887, Brazil

    Fernanda Viviane Mariano

Authors
  1. Beatriz Samara de Brito
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  2. Natália Giovanelli Gaspar
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  3. Erika Said Abu Egal
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  4. Celeste Sanchez-Romero
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  5. Antonio Santos Martins
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  6. Álfio José Tincani
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  7. Rogério de Oliveira Gondak
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  8. Oslei Paes de Almeida
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  9. Luiz Paulo Kowalski
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  10. Albina Altemani
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  11. Fernanda Viviane Mariano
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Corresponding author

Correspondence to Fernanda Viviane Mariano.

Ethics declarations

The current study was carried out in accordance with the ethical guidelines of our institution (Process number 834.605 from Plataforma Brazil).

Funding

Process FAPESP: 2014/18312-1, FAPESP: 2011/23366-5, FAPESP: 2011/23204-5.

Conflict of interest

The authors declare that they have no conflict of interest.

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de Brito, B.S., Gaspar, N.G., Egal, E.S.A. et al. PLAG1 expression is maintained in recurrent pleomorphic adenoma. Virchows Arch 469, 477–481 (2016). https://doi.org/10.1007/s00428-016-1980-3

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  • DOI: https://doi.org/10.1007/s00428-016-1980-3

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