Multifocal cytokeratin expression in pleural and abdominal malignant solitary fibrous tumors: an unusual diagnostic pitfall
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Solitary fibrous tumor (SFT) is an uncommon mesenchymal fibroblastic neoplasm usually arising in the pleura, but it can virtually affect any extrapleural site. Conventional SFTs are characterized by short, cytologically bland spindle cells arranged in a patternless architecture, a fibro-collagenous stroma, and a prominent hemangiopericytomatous branching vascular network . The vast majority of SFTs are morphologically and clinically benign. However, 5 to 10 % of SFTs will recur and/or metastasize. Proposed prognostic clinical and morphological criteria for SFT include age at presentation, tumor size, cellularity, mitotic activity (>4 mitoses per 10 high-power fields), the presence of necrosis, and the presence of sharply demarcated anaplastic areas. The vast majority of aggressive SFTs demonstrate these clinical and morphological features of malignancy; however, also morphologically benign-appearing SFTs can metastasize, and therefore, the biological behavior of this...
KeywordsSolitary Fibrous Tumor Cytokeratin Expression CD34 Reactivity Atypical Spindle Cell Malignant Solitary Fibrous Tumor
Conflict of interest
The authors declare no conflict of interest.
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