Virchows Archiv

, Volume 463, Issue 4, pp 553–562 | Cite as

Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma

  • Fumiyoshi Fushimi
  • Kenichi Taguchi
  • Hiroto Izumi
  • Kimitoshi Kohno
  • Michihiko Kuwano
  • Mayumi Ono
  • Yutaka Nakashima
  • Tetsuro Takesue
  • Seiji Naito
  • Yoshinao OdaEmail author
Original Article


Patients with end-stage renal disease are exposed to increased oxidative stress and impairment of antioxidant mechanisms. We focused on dialysis renal cell carcinoma (RCC), including epithelial hyperplasia in acquired cystic disease of the kidney (ACDK). We attempted to obtain insight into the carcinogenesis and tumor progression in terms of cellular defense mechanisms associated with oxidative stress by investigating the expression of antioxidant proteins by immunohistochemistry. We evaluated retrospectively 43 cases of dialysis RCC and, as a control group, 49 cases of sporadic RCC. Peroxiredoxin (Prx) 1, 3, 4, 5, and 6 expression in dialysis RCC was positively correlated with the duration of dialysis. In epithelial hyperplasia, in 17 cases of acquired cystic disease of the kidney, Prxs and thioredoxin were highly expressed. Moreover, in dialysis RCC, Prx 3, 4, and 5 immunoreactivity and nuclear expression of Y-box-binding protein-1 were higher than in sporadic RCC. In dialysis RCC, Prx 3, 4, and 5 immunoreactivity positively correlated with the Fuhrman nuclear grade. These data suggest that oxidative stress during dialysis enhances antioxidant activity, with an inhibiting effect on carcinogenesis. Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC.


Oxidative stress Peroxiredoxin Y-box-binding protein-1 Renal cell carcinoma Acquired cystic disease of kidney 



This study was supported by a Grant-in-Aid for Challenging Exploratory Research (no. 24650646) from the Japan Society for the Promotion of Science, Tokyo, Japan. We are grateful to Mr. Steve Cotton, Aso Corporation, for editing the English language in this manuscript.

Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Fumiyoshi Fushimi
    • 1
  • Kenichi Taguchi
    • 2
  • Hiroto Izumi
    • 3
  • Kimitoshi Kohno
    • 3
  • Michihiko Kuwano
    • 4
  • Mayumi Ono
    • 4
  • Yutaka Nakashima
    • 5
  • Tetsuro Takesue
    • 6
  • Seiji Naito
    • 7
  • Yoshinao Oda
    • 1
    Email author
  1. 1.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityHigashi-kuJapan
  2. 2.Department of PathologyNational Kyushu Cancer CenterMinami-kuJapan
  3. 3.Department of Molecular BiologyUniversity of Occupational and Environmental HealthKitakyushuJapan
  4. 4.Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical SciencesKyushu UniversityHigashi-kuJapan
  5. 5.Department of PathologyFukuoka Red Cross HospitalMinami-kuJapan
  6. 6.Department of UrologyFukuoka Red Cross HospitalMinami-kuJapan
  7. 7.Department of Urology, Graduate School of Medical SciencesKyushu UniversityHigashi-kuJapan

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