BMI1 expression identifies subtypes of Merkel cell carcinoma
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Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma. The aims of this study were to investigate the expression of the transcription factors B-lymphoma Moloney murine leukaemia virus insertion (BMI1), myelocytomatosis viral oncogene homologue (c-Myc) and Snail in MCC tumour specimens and to examine the relationship of these markers to Merkel cell polyoma virus (MCV). The study comprised of 133 patients with primary MCC. The expression of BMI1, Snail and c-Myc protein was assessed by immunohistochemistry and compared with clinical parameters, MCV status and patient survival. The presence of MCV was inversely correlated with the expression of BMI1 protein. Tumours expressing BMI1 protein more often presented with lymph node metastases. Snail protein expression was decreased in cases with metastatic dissemination. This study identified two subgroups of MCC: tumours expressing BMI1 but negative for MCV DNA and tumours negative for BMI1 expression but positive for MCV. Importantly, BMI1-positive cases often presented with lymph node metastases. Combined, these results suggest that subtypes of this malignancy exist.
KeywordsMerkel cell carcinoma BMI1 Merkel cell polyoma virus
American Joint Committee on Cancer
B-lymphoma Moloney murine leukaemia virus insertion
Myelocytomatosis viral oncogene homologue
Large T 3
Merkel cell carcinoma
Merkel cell polyoma virus
Polymerase chain reaction
Thyroid transcription factor-1
The authors thank Päivi Peltokangas, Tuire Koski and Elina Aspiala for excellent technical assistance. Harri Sihto is thanked for MCV analysis and Timo Pessi for assistance with statistical analysis. Funding of this study was from departmental sources only.
Conflict of interest
Each author declares no financial conflicts of interest with regard to the data presented in this manuscript.
- 35.Edge SB, Byrd DR, Compton CC (eds) (2010) Merkel cell carcinoma. Springer, New York, pp 315–323Google Scholar