Virchows Archiv

, 459:495 | Cite as

Aggressive B cell lymphomas of the gastrointestinal tract: clinicopathologic and genetic analysis

  • Song-Yi Choi
  • Seok Jin Kim
  • Won Seog Kim
  • Kihyun Kim
  • Young-Hyeh Ko
Original Article

Abstract

Aggressive B cell lymphomas of the gastrointestinal tract include Burkitt lymphoma (BL), diffuse large B cell lymphoma, and B cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL. To investigate the clinical characters of DLBCL/BL of the gastrointestinal (GI) tract, 101 cases of aggressive B cell lymphoma of the GI tract were analyzed by immunohistochemistry and fluorescence in situ hybridization (FISH) using break apart probe for c-MYC gene. For cases with c-MYC rearrangement, additional FISH studies with MYC/IgH fusion probe, BCL2 break apart probe, and BCL6 break apart probe were performed. MYC rearrangement was detected in 23 of 101 cases of aggressive B cell lymphomas (22.5%). The cases with MYC rearrangement were divided into 14 BL, three DLBCL/BL, and six DLBCL. One of the three DLBCL/BL had double translocation for MYC and BCL6 gene. Clinically, DLBCL/BL of the GI tract was more akin to Burkitt lymphoma than it is to GI tract DLBCL with c-MYC rearrangement. The overall prognosis of patients with DLBCL/BL was the worst among aggressive B cell lymphomas. DLBCL/BL is uncommon category of B cell lymphoma in the GI tract with aggressive clinical course despite of intensive chemotherapy.

Keywords

Gray zone lymphoma Burkitt lymphoma Diffuse large B cell lymphoma Intermediate lymphoma c-MYC 

Notes

Acknowledgment

This study is supported by Samsung Biomedical Research Institute grant(C-B0-202-2) and a grant of the Korea Health Care technology R&D Project, Ministry for Health & Welfare Affairs, Republic of Korea (A092255).

Conflict of interest statement

We declare that we have no conflict of interest

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Song-Yi Choi
    • 1
  • Seok Jin Kim
    • 2
  • Won Seog Kim
    • 2
  • Kihyun Kim
    • 2
  • Young-Hyeh Ko
    • 3
  1. 1.Department of PathologyChungbuk National University HospitalCheongjuSouth Korea
  2. 2.Division of Hematology-Oncology, Department of MedicineSungkyunkwan University School of MedicineSeoulRepublic of Korea
  3. 3.Department of Pathology, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

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