Virchows Archiv

, 459:361

Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma

  • Mona A. A. Zaki
  • Naoki Wada
  • Junichiro Ikeda
  • Hirohiko Shibayama
  • Koji Hashimoto
  • Tamotsu Yamagami
  • Yoichi Tatsumi
  • Machiko Tsukaguchi
  • Hironori Take
  • Mitsuru Tsudo
  • Eiichi Morii
  • Katsuyuki Aozasa
Original Article

DOI: 10.1007/s00428-011-1140-8

Cite this article as:
Zaki, M.A.A., Wada, N., Ikeda, J. et al. Virchows Arch (2011) 459: 361. doi:10.1007/s00428-011-1140-8

Abstract

To evaluate roles of tumor-associated macrophages (TAMs) for prognosis of classical Hodgkin lymphoma (CHL). Expression of markers for TAMs, CD68, HLA-DR, CD163, HLA-DR/CD68 (M1), and CD163/CD68 (M2) was immunohistochemically examined in 82 cases with CHL. Positively stained cells were counted and correlation of number of TAMs and patients’ survival time was analyzed. Number of CD163+ cells and M2 cells was significantly correlated with shorter overall survival (P < 0.05), while it was marginally significant for CD68+ cells (P = 0.0827). HLA-DR + cells and M1 cells showed no significant correlation with overall survival. When confined to mixed cellularity subtype, number of M1 cells was correlated with favorable prognosis (P < 0.05), while M2 did not (P = 0.7). Older age and male sex were unfavorable factors for prognosis. At multivariate analysis, number of CD163+ cells, M2+ cells, and age were independent factors for poor overall survival (P = 0.03, 0.02, and 0.01, respectively). CD163+ cells and M2 cells might work to be tumor promotive in CHL. M1 cells might be tumor suppressive in mixed cellularity type.

Keywords

Tumor-associated macrophages M1 type M2 type Hodgkin lymphoma Immunohistochemistry Double staining Prognosis 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Mona A. A. Zaki
    • 1
  • Naoki Wada
    • 1
  • Junichiro Ikeda
    • 1
  • Hirohiko Shibayama
    • 2
  • Koji Hashimoto
    • 3
  • Tamotsu Yamagami
    • 4
  • Yoichi Tatsumi
    • 5
  • Machiko Tsukaguchi
    • 6
  • Hironori Take
    • 7
  • Mitsuru Tsudo
    • 8
  • Eiichi Morii
    • 1
  • Katsuyuki Aozasa
    • 1
  1. 1.Department of Pathology (C3)Osaka University Graduate School of MedicineSuitaJapan
  2. 2.Department of Hematology and OncologyOsaka University Graduate School of MedicineSuitaJapan
  3. 3.Department of Internal MedicineKansai Rosai HospitalAmagasakiJapan
  4. 4.Department of HematologyNTT West Osaka HospitalOsakaJapan
  5. 5.Department of HematologyKinki University School of MedicineOsakasayamaJapan
  6. 6.Department of HematologySakai Municipal HospitalSakaiJapan
  7. 7.Department of Internal MedicineToyonaka Municipal HospitalToyonakaJapan
  8. 8.Department of HematologyOsaka Red Cross HospitalOsakaJapan

Personalised recommendations