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Virchows Archiv

, Volume 456, Issue 2, pp 167–179 | Cite as

Well-differentiated and dedifferentiated liposarcomas

  • Jean-Michel Coindre
  • Florence Pédeutour
  • Alain Aurias
Review and Perspective

Abstract

Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.

Keywords

Well-differentiated liposarcoma Dedifferentiated liposarcoma MDM2 CDK4 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jean-Michel Coindre
    • 1
    • 2
    • 5
  • Florence Pédeutour
    • 3
  • Alain Aurias
    • 4
  1. 1.Department of Pathology and INSERM U916Institut BergoniéBordeauxFrance
  2. 2.Laboratory of PathologyUniversity Victor SégalenBordeauxFrance
  3. 3.Laboratoire de Génétique Somatique des Tumeurs SolidesCHU de Nice et CNRS UMR 6543, Faculté de MédecineNiceFrance
  4. 4.Genetics and Biology of Cancers and INSERM U830Institut CurieParisFrance
  5. 5.Department of PathologyInstitut BergoniéBordeaux CédexFrance

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