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Virchows Archiv

, Volume 454, Issue 3, pp 333–339 | Cite as

Dendritic cell sarcomas/tumours of the breast: report of two cases

  • Nilgun Kapucuoglu
  • Sıbel Percinel
  • Terenzio Ventura
  • RongGang Lang
  • Wael Al-Daraji
  • Vincenzo EusebiEmail author
Case Report

Abstract

Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year-old woman who both showed a firm lump in the left breast. The FDCS/T lesion superficially appeared as an anaplastic carcinoma and the IDCS/T was reminiscent of a spindle cell sarcomatoid carcinoma. Nevertheless both lesions were negative for keratins while case 1 displayed neoplastic cells strongly positive for CD21, vimentin and focally for CD68 and S-100 protein. The tumour cells of case 2 were positive for S-100, CD68 and CD45. In breast, an unusual keratin negative tumour composed predominantly of spindle cells arranged in fascicles, storiform pattern or whorls with a lymphoid rich stroma should raise suspicion for FDCS/Ts or IDCS/Ts. The distinction from malignant tumours with similar features is discussed.

Keywords

Breast Follicular dendritic cell sarcoma Interdigitating dendritic cell sarcoma Dendritic cell tumour Immunohistochemistry 

Notes

Conflict of interest statement

The authors declare that they have no conflict of interest.

References

  1. 1.
    Pileri SA, Grogan TM, Haris NL et al (2002) Tumors of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 41:1–29PubMedCrossRefGoogle Scholar
  2. 2.
    Fonseca R, Yamakawa M, Nakamura S et al (1998) Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. Am J Hematol 59:161–167PubMedCrossRefGoogle Scholar
  3. 3.
    Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) (2001) World Health Organization Classification of Tumors. Pathology and genetics of tumors of haemotopoietic and lymphoid tissues. IARC, LyonGoogle Scholar
  4. 4.
    Monda L, Warnke R, Rosai J (1986) A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation. A report of 4 cases. Am J Pathol 122:562–572PubMedGoogle Scholar
  5. 5.
    Soriano AO, Thompson MA, Admirand JH et al (2007) Follicular dendritic cell sarcoma: a report of 14 cases and review of the literature. Am J Hematol 82:725–728PubMedCrossRefGoogle Scholar
  6. 6.
    Shia J, Chen W, Tang LH et al (2006) Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity. Virchows Arch 449:148–158PubMedCrossRefGoogle Scholar
  7. 7.
    Fisher C, Magnusson B, Hardarson S, Smith MEF (1999) Myxoid variant of follicular dendritic cell sarcoma arising in the breast. Ann Diagn Pathol 3:92–98PubMedCrossRefGoogle Scholar
  8. 8.
    Pruneri G, Masullo M, Renne G et al (2002) Follicular dendritic cell sarcoma of the breast. Virchows Arch 441:194–199PubMedCrossRefGoogle Scholar
  9. 9.
    Barwell N, Howatson R, Jackson R et al (2004) Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol 57:87–89PubMedCrossRefGoogle Scholar
  10. 10.
    Sharma M, Ahsan F, Ah-See KW et al (2006) Interdigitating dendritic cell sarcoma of the parotid gland. J Laryngol Otol 120:244–246PubMedGoogle Scholar
  11. 11.
    Uluoğlu Ö, Akyürek N, Üner A et al (2005) Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature. Virchows Arch 446:546–554PubMedCrossRefGoogle Scholar
  12. 12.
    Hammond LA, Keh C, Rowlands DC (1996) Rosai-Dorfman disease in the breast. Histopathology 29:582–584PubMedCrossRefGoogle Scholar
  13. 13.
    Dadmanesh F, Peterse JL, Sapino A et al (2001) Lymphoepithelioma-like carcinoma of the breast: lack of evidence of Epstein-Barr virus infection. Histopathology 38:54–61PubMedCrossRefGoogle Scholar
  14. 14.
    Chang KC, Jin YT, Chen FF, Su IJ (2001) Follicular dendritic cell sarcoma of the colon mimicking stromal tumor. Histopathology 38:148–157CrossRefGoogle Scholar
  15. 15.
    Han JH, Kim SH, Noh SH et al (2000) Follicular dendritic cell sarcoma presenting as a submucosal tumor of the stomach. Arch Pathol Lab Med 124:1693–1696PubMedGoogle Scholar
  16. 16.
    Hollowood JD, Stamp G, Zouvani J, Fletcher CDM (1995) Extranodal follicular dendritic cell sarcoma of the gastrointestinal tract. Morphologic, immunohistochemical and ultrastructural analysis of two cases. Am J Clin Pathol 103:90–97PubMedGoogle Scholar
  17. 17.
    Chan JKC (1997) Proliferative lesions of follicular dendritic cells: an overview, including a detailed account of follicular dendritic cell sarcoma, a neoplasm with many faces and uncommon etiologic associations. Adv Anat Pathol 4:387–411Google Scholar
  18. 18.
    Chan JKC, Fletcher CDM, Nayler SJ, Cooper K (1997) Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting malignant porential higher than currently recognized. Cancer 79:294–313PubMedCrossRefGoogle Scholar
  19. 19.
    Fornelli A, Mureden A, Eusebi V (1998) Tumore a cellule follicolari dendritiche e lesione vascolare insorti in linfonodo con malattia di Castleman. Descrizione di un caso. Pathologica 90:146–151PubMedGoogle Scholar
  20. 20.
    Luk ISC, Shek TWH, Tang VWL, Ng WF (1993) Interdigitating dendtritic cell tumor of the testis. A novel testicular spindle cell neoplasm. Am J Surg Pathol 23:1141–1148CrossRefGoogle Scholar
  21. 21.
    Lammie GA, Bobrow LG, Staunton MDM et al (1991) Sclerosing lymphocytic lobulitis of the breast—evidence for an autoimmune pathogenesis. Histopathology 19:13–20PubMedCrossRefGoogle Scholar
  22. 22.
    Tavassoli FA, Eusebi V (2008) Tumors of the breast, 4th edn. American Registry of Pathology/AFIP, Washington, DCGoogle Scholar
  23. 23.
    Chen TC, Kuo TT, Ng KF (2001) Follicular dendritic cell tumor of the liver: a clinicopathologic and Epstein-Barr virus study of the two cases. Mod Pathol 14:354–360PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Nilgun Kapucuoglu
    • 1
  • Sıbel Percinel
    • 2
  • Terenzio Ventura
    • 3
  • RongGang Lang
    • 4
  • Wael Al-Daraji
    • 5
  • Vincenzo Eusebi
    • 6
    Email author
  1. 1.Department of PathologySuleyman Demirel UniversityIspartaTurkey
  2. 2.Department of PathologyAnkara UniversityAnkaraTurkey
  3. 3.Department of PathologyUniversità dell’AquilaL’AquilaItaly
  4. 4.Department of Breast Cancer Pathology and Laboratory Medicine, Cancer HospitalTianjin Medical UniversityTianjinChina
  5. 5.Department of PathologyUniversity of NottinghamNottinghamUK
  6. 6.Istituto di Anatomia ed Istologia PatologicaUniversità di BolognaBolognaItaly

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