Virchows Archiv

, Volume 454, Issue 3, pp 333–339 | Cite as

Dendritic cell sarcomas/tumours of the breast: report of two cases

  • Nilgun Kapucuoglu
  • Sıbel Percinel
  • Terenzio Ventura
  • RongGang Lang
  • Wael Al-Daraji
  • Vincenzo EusebiEmail author
Case Report


Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year-old woman who both showed a firm lump in the left breast. The FDCS/T lesion superficially appeared as an anaplastic carcinoma and the IDCS/T was reminiscent of a spindle cell sarcomatoid carcinoma. Nevertheless both lesions were negative for keratins while case 1 displayed neoplastic cells strongly positive for CD21, vimentin and focally for CD68 and S-100 protein. The tumour cells of case 2 were positive for S-100, CD68 and CD45. In breast, an unusual keratin negative tumour composed predominantly of spindle cells arranged in fascicles, storiform pattern or whorls with a lymphoid rich stroma should raise suspicion for FDCS/Ts or IDCS/Ts. The distinction from malignant tumours with similar features is discussed.


Breast Follicular dendritic cell sarcoma Interdigitating dendritic cell sarcoma Dendritic cell tumour Immunohistochemistry 


Conflict of interest statement

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Nilgun Kapucuoglu
    • 1
  • Sıbel Percinel
    • 2
  • Terenzio Ventura
    • 3
  • RongGang Lang
    • 4
  • Wael Al-Daraji
    • 5
  • Vincenzo Eusebi
    • 6
    Email author
  1. 1.Department of PathologySuleyman Demirel UniversityIspartaTurkey
  2. 2.Department of PathologyAnkara UniversityAnkaraTurkey
  3. 3.Department of PathologyUniversità dell’AquilaL’AquilaItaly
  4. 4.Department of Breast Cancer Pathology and Laboratory Medicine, Cancer HospitalTianjin Medical UniversityTianjinChina
  5. 5.Department of PathologyUniversity of NottinghamNottinghamUK
  6. 6.Istituto di Anatomia ed Istologia PatologicaUniversità di BolognaBolognaItaly

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