Virchows Archiv

, Volume 453, Issue 6, pp 611–616 | Cite as

Lymphocyte-depleted classic Hodgkin lymphoma—a neglected entity?

  • Daniel Benharroch
  • Amalia Levy
  • Jacob Gopas
  • Martin Sacks
Original Article


Changes in the definition of lymphocyte-depleted classic Hodgkin lymphoma (LDcHL) have recently led to reclassification of many cases as other pleomorphic lymphomas. We have set out to identify LD cases in our cohort of cHL patients and determine their clinical and biological characteristics properties. We defined the morphologic picture of LDcHL according to selected criteria and determined how its features differ from those of other subtypes of cHL. Twelve of 201 cHL patients (5.9%) were diagnosed as showing LDcHL histology, a higher percentage of LDcHL than in most recent series. The LD cases were most often positive for Epstein–Barr virus and for sialyl-CD15. Defining the cases as either reticular (eight) or as diffuse fibrosis (three) variants was critical to the diagnostic approach. We conclude that LDcHL may be a neglected entity.


Hodgkin lymphoma Lymphocyte-depleted Reticular Diffuse fibrosis 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Daniel Benharroch
    • 1
    • 5
  • Amalia Levy
    • 2
  • Jacob Gopas
    • 3
    • 4
  • Martin Sacks
    • 1
  1. 1.Department of PathologySoroka University Medical CenterBeer-ShevaIsrael
  2. 2.Department of Epidemiology, Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael
  3. 3.Department of OncologySoroka University Medical CenterBeer-ShevaIsrael
  4. 4.Department of Microbiology-Immunology, Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael
  5. 5.Hematopathology Unit, Department of PathologySoroka University Medical CenterBeer-ShevaIsrael

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