Virchows Archiv

, 453:589 | Cite as

Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection

  • Kee-Taek Jang
  • Seung-Mo Hong
  • Kyu Taek Lee
  • Jong Gyun Lee
  • Seoung Ho Choi
  • Jin Seok Heo
  • Dong Wook Choi
  • Dongil Choi
  • Jae Hoon Lim
Original Article

Abstract

Intraductal papillary neoplasm of bile duct (IPNB) is one of the precursor lesions of cholangiocarcinoma. Although hepatolithiasis has been extensively studied in its association with IPNBs, there had been no comprehensive study of IPNBs with Clonorchis sinensis infection. Twelve IPNBs were selected from 20 surgically resected cholangiocarcinomas, positive for C. sinensis tests (60%) and compared with eight IPNBs, selected from 51 resected cholangiocarcinomas, negative for C. sinensis tests (16%), by histologic and immunohistochemical studies of mucin core proteins and cytokeratin panels. The predominant immuno-phenotype of IPNB cases with Clonorchiasis was pancreatobiliary type (MUC1+/MUC2-/CDX2-; 9/12 cases), while that of IPNB cases with negative for C. sinensis was intestinal type (MUC1-/MUC2+/CDX2+; 6/8; p = 0.04). The prevalence of IPNBs was higher when patients with cholangiocarcinoma had Clonorchiasis. IPNBs with Clonorchiasis tended to have a more pancreatobiliary phenotype, which suggests IPNBs with Clonorchiasis may have a different tumorigenesis pathway from IPNBs with other etiologies.

Keywords

Clonorchis sinensis Intraductal papillary neoplasm of bile duct 

Notes

Acknowledgements

We thank Ms. Margaret Griffith for editing the manuscript.

Conflicts of interest statement

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Kee-Taek Jang
    • 1
  • Seung-Mo Hong
    • 2
  • Kyu Taek Lee
    • 3
  • Jong Gyun Lee
    • 3
  • Seoung Ho Choi
    • 4
  • Jin Seok Heo
    • 4
  • Dong Wook Choi
    • 4
  • Dongil Choi
    • 5
  • Jae Hoon Lim
    • 5
  1. 1.Department of Pathology, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Department of PathologyJohns Hopkins Medical InstitutionsBaltimoreUSA
  3. 3.Department of Medicine, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSeoulKorea
  4. 4.Department of Surgery, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSeoulKorea
  5. 5.Department of Radiology and Center for Imaging Science, Samsung Medical Center, and Center of Clinical Research, Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSeoulSouth Korea

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