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Virchows Archiv

, Volume 453, Issue 2, pp 171–176 | Cite as

Lymph node pathology in pulmonary veno-occlusive disease and pulmonary capillary heamangiomatosis

  • Vincent Thomas de Montpréville
  • Élisabeth Dulmet
  • Élie Fadel
  • Philippe Dartevelle
Original Article

Abstract

To assess the histological bases of lymphadenomegaly, which has been reported as a frequent radiological finding in pulmonary veno-occlusive disease (PVOD), we have reviewed pulmonary and mediastinal lymph nodes resected during lung transplantations in 19 patients suffering from PVOD and related pulmonary capillary haemangiomatosis (PCH). Lymphatic congestion was common and was often obvious in subsegmental and segmental lymph nodes. Vascular transformation of the sinuses, intra-sinusal haemorrhage with erythrophagocytosis and lymphoid follicular hyperplasia were frequent especially in lobar, hilar and mediastinal lymph nodes. These lesions were very significantly less frequent in 33 cases of pulmonary hypertension unrelated to PVOD. Due to their thoracic location, these non-specific lesions could simulate other diagnoses such as Castleman disease or lymphangioleiomyomatosis. However, in the setting of pulmonary hypertension, they should suggest PVOD and PCH. They are probably secondary to venous congestion, veno-lymphatic shunts and angiogenetic factors associated with these diseases.

Keywords

Pulmonary veno-occlusive disease Pulmonary capillary haemangiomatosis Lymph nodes Vascular transformation of sinuses Erythrophagocytosis 

Notes

Acknowledgements

The authors thank Miss Dominique Gimont, Mrs Magalie Guerini and Miss Sylvie Planté for their technical assistance and Mrs Marylaure Legentil and Mrs Angélique Roggia for their secretarial work.

Conflict of interest statement

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Vincent Thomas de Montpréville
    • 1
    • 3
  • Élisabeth Dulmet
    • 1
  • Élie Fadel
    • 2
  • Philippe Dartevelle
    • 2
  1. 1.Department of PathologyMarie Lannelongue Surgical CentreLe Plessis RobinsonFrance
  2. 2.Department of Thoracic and Vascular Surgery and Heart-Lung TransplantationMarie Lannelongue Surgical CentreLe Plessis RobinsonFrance
  3. 3.Service d’anatomie pathologiqueCentre chirurgical Marie LannelongueLe Plessis RobinsonFrance

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