Virchows Archiv

, Volume 453, Issue 2, pp 197–201

Mixed-type liposarcoma: clinicopathological, immunohistochemical, and molecular analysis of a case arising in deep soft tissues of the lower extremity

  • Thomas Mentzel
  • Gabriele Palmedo
  • Markus Hantschke
  • Jörg Woziwodzki
  • Christian Beck
Case Report


A rare case of mixed-type liposarcoma arising in deep soft tissue of the right thigh of a 45-year-old female patient is reported. The neoplasm was completely excised and was composed of an irregular admixture of areas of atypical lipomatous tumor/well-differentiated liposarcoma of the lipoma-like subtype with areas of myxoid/round cell liposarcoma. An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.


Liposarcoma Mixed-type liposarcoma MDM2 CDK4 CHOP FUS Immunohistochemistry Cytogenetics 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Thomas Mentzel
    • 1
  • Gabriele Palmedo
    • 1
  • Markus Hantschke
    • 1
  • Jörg Woziwodzki
    • 2
  • Christian Beck
    • 3
  1. 1.Dermatopathologische GemeinschaftspraxisFriedrichshafenGermany
  2. 2.Department of PathologyAurichGermany
  3. 3.Department of SurgeryVarelGermany

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