Virchows Archiv

, Volume 452, Issue 3, pp 343–345 | Cite as

Hibernoma-like brown fat in the bone marrow: report of a unique case

  • C. Thorns
  • C. Schardt
  • D. Katenkamp
  • C. Kähler
  • H. Merz
  • A. C. Feller
Case Report

Abstract

We report on a bone-marrow biopsy of a 61-year-old female patient that was performed because of the clinical suspicion of a myeloproliferative disease. The trephine biopsy showed morphological features that were consistent with an essential thrombocythaemia (ET). The diagnosis of a myeloproliferative disease could be corroborated by demonstration of the V617F mutation of JAK2. Besides the histological features of ET, the marrow showed a peculiar infiltrate that consisted of multivacuolated cells that were immunohistochemically identified as brown adipose tissue with a hibernoma-like picture. To the best of our knowledge, this is the first report on brown adipose tissue in the bone marrow.

Keywords

Trephine bone marrow biopsy Immunohistochemical stainings Brown adipose tissue 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • C. Thorns
    • 1
  • C. Schardt
    • 2
  • D. Katenkamp
    • 3
  • C. Kähler
    • 1
  • H. Merz
    • 1
  • A. C. Feller
    • 1
  1. 1.Institut für Pathologie und Konsultations-und Referenzzentrum für Lymphknotendiagnostik und HämatopathologieUniversitätsklinikum Schleswig-HolsteinLübeckGermany
  2. 2.Onkologische SchwerpunktpraxisGelsenkirchenGermany
  3. 3.Institut für Pathologie und Konsultations-und Referenzzentrum für WeichgewebstumorenUniversitätsklinikum JenaJenaGermany

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