Virchows Archiv

, Volume 451, Issue 5, pp 923–928

Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature

  • Daniel Baumhoer
  • Kathrin Glatz
  • Hans-Jürgen Schulten
  • László Füzesi
  • Renato Fricker
  • Christoph Kettelhack
  • Paula Hasenboehler
  • Martin Oberholzer
  • Gernot Jundt
Original Article

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade sarcoma of the distal extremities characterized by a myxohyaline stroma, a dense inflammatory infiltrate and virocyte- and lipoblast-like giant cells. Up to now, only two cases have been investigated cytogenetically, showing complex and heterogeneous karyotypes, in part with supernumerary ring chromosomes. We characterized two further cases of MIFS immunohistochemically and performed comparative genomic hybridization as well as DNA image cytometry analyses. Both tumors showed the characteristic histomorphological pattern of MIFS and were positive for Vimentin and CD68. Moreover, both cases presented aberrant karyotypes including distinct DNA copy number changes involving chromosome 7 and disclosed DNA aneuploidy.

Keywords

Myxoinflammatory fibroblastic sarcoma Comparative genomic hybridization CGH DNA image cytometry Review 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Daniel Baumhoer
    • 1
  • Kathrin Glatz
    • 1
  • Hans-Jürgen Schulten
    • 3
  • László Füzesi
    • 3
  • Renato Fricker
    • 4
  • Christoph Kettelhack
    • 5
  • Paula Hasenboehler
    • 6
  • Martin Oberholzer
    • 1
  • Gernot Jundt
    • 1
    • 2
  1. 1.Institute of PathologyUniversity of BaselBaselSwitzerland
  2. 2.Bone Tumor Reference Center at the Institute of PathologyUniversity of BaselBaselSwitzerland
  3. 3.Department of PathologyUniversity of GöttingenGöttingenGermany
  4. 4.Department of SurgeryKantonsspital BruderholzBruderholzSwitzerland
  5. 5.Department of SurgeryUniversity of BaselBaselSwitzerland
  6. 6.Department of SurgeryBethesda SpitalBaselSwitzerland

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