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Virchows Archiv

, Volume 450, Issue 3, pp 297–302 | Cite as

Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer

  • Guangying Qi
  • Ikuko Ogawa
  • Yasusei Kudo
  • Mutsumi Miyauchi
  • B. S. M. S. Siriwardena
  • Fumio Shimamoto
  • Masaaki Tatsuka
  • Takashi Takata
Original Article

Abstract

Aurora-B kinase is a chromosomal passenger protein and is essential for chromosome segregation and cytokinesis. Aurora-B overexpression in various cancer cells induces chromosomal number instability to produce multinuclearity and relates to metastasis. Here, we examined the expression of Aurora-B in oral squamous cell carcinoma (OSCC) to elucidate the relationship between Aurora-B expression and clinico-pathological findings by immunohistochemistry. Aurora-B expression was observed in normal oral squamous epithelia and OSCC cases, but the number of positive cells was significantly higher in OSCC than in normal squamous epithelium (p < 0.01). The labeling index of Aurora-B was significantly correlated with lymph node metastasis (p < 0.01) and histological grades of differentiation (p < 0.01). We also compared Aurora-B expression with Ki-67 expression and a positive correlation was found (p < 0.0001). Moreover, Aurora-B expression is significantly more frequent in multinuclear tumor cells than in total tumor cells. In summary, we found that Aurora-B expression was well correlated with cell proliferation, induction of multinuclear cells, histological differentiation, and metastasis in OSCC. These findings suggest that Aurora-B may be involved in tumor progression and that Aurora-B can be a new diagnostic and therapeutic target for OSCC.

Keywords

Oral squamous cell carcinoma Aurora-B Cell proliferation Metastasis Multinuclear cells 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Guangying Qi
    • 1
  • Ikuko Ogawa
    • 2
  • Yasusei Kudo
    • 1
  • Mutsumi Miyauchi
    • 1
  • B. S. M. S. Siriwardena
    • 1
  • Fumio Shimamoto
    • 3
  • Masaaki Tatsuka
    • 4
  • Takashi Takata
    • 1
  1. 1.Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Center of Oral Clinical ExaminationHiroshima University HospitalHiroshimaJapan
  3. 3.Graduate School of Human Life and Environmental SciencePrefectural University of HiroshimaHiroshimaJapan
  4. 4.Department of Molecular Radiobiology, Research Institute of Radiation Biology for MedicineHiroshima UniversityHiroshimaJapan

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