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Virchows Archiv

, Volume 450, Issue 2, pp 187–194 | Cite as

Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients

  • Verena Materna
  • Paweł Surowiak
  • Irina Kaplenko
  • Marek Spaczyński
  • Zhenfeng Duan
  • Maciej Zabel
  • Manfred Dietel
  • Hermann LageEmail author
Original Article

Abstract

An obstacle in chemotherapy of ovarian cancer is the development of drug resistance. Taxol (paclitaxel)-resistance-associated gene-3 (TRAG-3/CSAG2) was found to be overexpressed in a paclitaxel-resistant ovarian carcinoma cell line. However, clinical impact of TRAG-3 in ovarian carcinoma has not been demonstrated previously. For demonstration of potential clinical impact of TRAG-3, immunohistochemistry was applied to determine TRAG-3 protein expression in specimens obtained from ovarian carcinoma patients (n = 37) who received a paclitaxel-based chemotherapy at two different time points, initial laparotomy before chemotherapy, and secondary cytoreduction after chemotherapy. The TRAG-3-specific immunohistochemical staining was correlated with clinical outcome. In ovarian carcinoma specimens obtained at the initial laparotomy, an advantage in overall (P < 0.001) and progression-free (P = 0.003) survival for patients with weak TRAG-3 expression could be demonstrated. Tumor specimens excised at secondary cytoreduction procedure were not predictive for clinical outcome. In summary, TRAG-3 was found to be a prognostic factor for the prediction of clinical outcome after the application of paclitaxel-based chemotherapy.

Keywords

Ovarian carcinoma Paclitaxel TRAG-3 CSAG2 Chemotherapy 

Notes

Acknowledgements

This study was supported in part by the “Berliner Krebsgesellschaft e.V.” and by grant LA 1039/2-3 of the “Deutsche Forschungsgemeinschaft”.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Verena Materna
    • 1
  • Paweł Surowiak
    • 1
    • 2
    • 3
  • Irina Kaplenko
    • 4
  • Marek Spaczyński
    • 4
  • Zhenfeng Duan
    • 5
  • Maciej Zabel
    • 2
    • 6
  • Manfred Dietel
    • 1
  • Hermann Lage
    • 1
    Email author
  1. 1.Institute of PathologyCharité Campus MitteBerlinGermany
  2. 2.Department of Histology and EmbryologyWrocław Medical UniversityWrocławPoland
  3. 3.Lower Silesian Center of OncologyWrocławPoland
  4. 4.Department of Obstetrics and GynecologyPoznań University of Medical SciencesPoznańPoland
  5. 5.Division of Hematology/OncologyMassachusetts General HospitalBostonUSA
  6. 6.Department of Histology and EmbryologyPoznań University of Medical SciencesPoznańPoland

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