Virchows Archiv

, Volume 449, Issue 6, pp 722–725

Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation. Study of its keratin profile

Case Report

Abstract

Oncocytic lipoadenomas of salivary gland are extremely rare tumors with only two previously reported cases. In this paper, we describe an additional example of oncocytic lipoadenoma showing sebaceous differentiation, a hitherto unreported occurrence. The tumor was encapsulated and measured 3 × 2.5 × 2 cm. Microscopically, the tumor comprised a mixture of oncocytes with “light” and “dark” cells intimately associated with mature adipose tissue. The oncocytes were positive for low molecular keratin, epithelial membrane antigen (EMA), and keratin 7, with only a small subgroup of cells expressing high-molecular-weight keratin, keratin 5/6, keratin 19, and p63. Terminally differentiated sebaceous cells were positive for EMA and keratin 14 only. Calponin and actins were negative, indicating a lack of myoepithelial cells in the tumor. The keratin profile and p63 expression of this oncocytic lipoadenoma suggest the presence of a dual cell population somewhat similar to the dual cell population described in some ultrastructural studies of pure salivary gland oncocytomas and may represent partial basal-cell differentiation. The presence and nature of a dual cell population in oncocytic neoplasms of salivary glands merit further investigation to confirm these observations.

Keywords

Parotid gland Salivary gland Lipoadenoma Oncocytoma 

References

  1. 1.
    Askew JB Jr, Bentinck DC, Jenson AB, Fechner RE (1971) Epithelial and myoepithelial oncocytes. Ultrastructural study of a salivary gland oncocytoma. Arch Otolaryngol 93:46–54PubMedGoogle Scholar
  2. 2.
    Barnes L, Eveson JW, Reichart P, Sidransky D (2005) Tumors of the salivary glands. World Health Organization classification of tumors. Pathology and genetics head and neck. IARC Press, Lyon, pp 209–281Google Scholar
  3. 3.
    Brandwein MS, Huvos AG (1991) Oncocytic tumors of major salivary glands: a study of 68 cases with follow-up of 44 patients. Am J Surg Pathol 15:514–528PubMedCrossRefGoogle Scholar
  4. 4.
    Dardick I, Kini S, Bradley G, Lee L, Leong I (2006) Salivary gland tumor cytopathology, oral and surgical pathology. Pathology Images Inc., OttawaGoogle Scholar
  5. 5.
    Ellis GL, Auclair PL (1996) Benign epithelial neoplasms. In: Rosai J, Sobin LH (eds) Tumors of the salivary glands. Atlas of tumor pathology, third series. Armed Forces Institute of Pathology, Washington, District of Columbia, pp 39–153Google Scholar
  6. 6.
    Gustafsson H, Kjorell U, Carlsoo B (1985) Cytoskeletal proteins in oncocytic tumors of the parotid gland. Arch Otolaryngol 111:99–105PubMedGoogle Scholar
  7. 7.
    Hirokawa M, Shimizu M, Manabe T, Ito J, Ogawa S (1998) Oncocytic lipoadenoma of the submandibular gland. Human Pathol 29:410–412CrossRefGoogle Scholar
  8. 8.
    Kato M, Horie Y (2000) Oncocytic lipoadenoma of the parotid gland. Histopathology 36:285–286PubMedCrossRefGoogle Scholar
  9. 9.
    Ozolek JA, Bastacky SI, Myers EN, Hunt JL (2005) Immunophenotypic comparison of salivary gland oncocytoma and metastatic renal cell carcinoma. Laryngoscope 115:1097–1100PubMedCrossRefGoogle Scholar
  10. 10.
    Reis-Filho JS, Simpson PT, Martins A, Preto A, Gartner F, Schmitt FC (2003) Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch 443:122–132PubMedCrossRefGoogle Scholar
  11. 11.
    Thompson LD, Wenig BM, Ellis GL (1996) Oncocytomas of the submandibular gland. A series of 22 cases and a review of the literature. Cancer 78:2281–2287PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of PathologyUniversity Health NetworkTorontoCanada
  2. 2.Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoCanada

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