Virchows Archiv

, Volume 449, Issue 5, pp 561–564 | Cite as

Anaplastic large-cell non-Hodgkin’s lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer—a case report

  • Florian Rudolf Fritzsche
  • Stefan Pahl
  • Iver Petersen
  • Mick Burkhardt
  • Anja Dankof
  • Manfred Dietel
  • Glen Kristiansen
Case Report


Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic infiltrate. The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma.


Lymphoma Breast cancer ALCL C-ALCL Immunohistochemistry 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Florian Rudolf Fritzsche
    • 1
  • Stefan Pahl
    • 1
  • Iver Petersen
    • 1
  • Mick Burkhardt
    • 1
  • Anja Dankof
    • 1
  • Manfred Dietel
    • 1
  • Glen Kristiansen
    • 1
  1. 1.Institute of PathologyCharité Universitätsmedizin BerlinBerlinGermany

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