Nephrogenic fibrosing dermopathy with involvement of the dura mater
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Nephrogenic fibrosing dermopathy (NFD) is a recently recognized cutaneous disorder that occurs in patients with end-stage renal disease, but which can also present with systemic involvement [1, 2]. Extracutaneous manifestations of this disease have been reported to involve the subcutaneous tissue, fascia, striated muscle, lungs, and myocardium . Recently, we examined a case of a 71-year-old man with NFD and diffuse calcification of the dura mater of the brain and spinal cord.
The patient's medical history included diet-controlled type 2 diabetes mellitus, hypertension, end-stage renal disease, peripheral vascular disease, atherosclerotic heart disease with anteroseptal myocardial infarction and coronary stenting in August 2005, and a seizure disorder of unknown etiology. He developed rapidly progressing NFD leading to marked flexion contractures of his extremities and debilitating pain. A CT scan of the head revealed prominent dural calcification of the interhemispheric...
KeywordsThalidomide Dura Mater Diffuse Calcification Atherosclerotic Heart Disease Nephrogenic Fibrosing Dermopathy