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Virchows Archiv

, Volume 449, Issue 3, pp 389–391 | Cite as

Nephrogenic fibrosing dermopathy with involvement of the dura mater

  • Adam Saenz
  • Rajni Mandal
  • Richard Kradin
  • E. Tessa Hedley-Whyte
Letter to the Editor

Dear Editor,

Nephrogenic fibrosing dermopathy (NFD) is a recently recognized cutaneous disorder that occurs in patients with end-stage renal disease, but which can also present with systemic involvement [1, 2]. Extracutaneous manifestations of this disease have been reported to involve the subcutaneous tissue, fascia, striated muscle, lungs, and myocardium [3]. Recently, we examined a case of a 71-year-old man with NFD and diffuse calcification of the dura mater of the brain and spinal cord.

The patient's medical history included diet-controlled type 2 diabetes mellitus, hypertension, end-stage renal disease, peripheral vascular disease, atherosclerotic heart disease with anteroseptal myocardial infarction and coronary stenting in August 2005, and a seizure disorder of unknown etiology. He developed rapidly progressing NFD leading to marked flexion contractures of his extremities and debilitating pain. A CT scan of the head revealed prominent dural calcification of the interhemispheric...

Keywords

Thalidomide Dura Mater Diffuse Calcification Atherosclerotic Heart Disease Nephrogenic Fibrosing Dermopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Adam Saenz
    • 1
  • Rajni Mandal
    • 1
  • Richard Kradin
    • 1
  • E. Tessa Hedley-Whyte
    • 1
  1. 1.Massachusetts General Hospital, Department of PathologyHarvard Medical SchoolBostonUSA

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