Virchows Archiv

, Volume 449, Issue 2, pp 244–247

Extramammary myofibroblastoma is genetically related to spindle cell lipoma

  • Francesca Maggiani
  • Maria Debiec-Rychter
  • Guy Verbeeck
  • Raf Sciot
Case Report


Extramammary-type myofibroblastoma is a rare, benign spindle cell lesion, strictly resembling the breast counterpart, but occurring in extramammary sites, mainly in the inguinal/groin area. In this paper, we describe an extramammary-type myofibroblastoma in the groin of a 37-year-old male patient. The tumor showed a typical morphological and immunophenotypical profile, including staining for both CD34 and desmin. Dual-color interphase florescent in situ hybridization analysis revealed losses of RB/13q14 and FKHR/13q14 loci within tumor cells. The chromosome 13 rearrangements associated with the loss of the 13q14 chromosomal region are typically seen in spindle cell lipoma, and have been previously recognized in mammary myofibroblastoma, providing strong evidence for a pathogenetic link between these lesions.


Mammary-type myofibroblastoma Spindle cell lipoma Immunohistochemistry Cytogenetics Chromosome 13 


  1. 1.
    Ali S, Teichberg S, DeRisi DC (1994) Giant myofibroblastoma of the male breast. Am J Surg Pathol 18:1170–1176PubMedCrossRefGoogle Scholar
  2. 2.
    Chan K-W, Ghadially FN, Alagaratnam TT (1984) Benign Spindle cell tumor of the breast: a variant of spindle cell lipoma or fibroma of breast. Pathology 16:331–336PubMedCrossRefGoogle Scholar
  3. 3.
    Dahlen A, Debiec-Rychter M, Pedeutour F, Domanski HA, Hoglund M, Bauer HC, Rydholm A, Sciot R, Mandahl N, Mertens F (2003) Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. Int J Cancer 103:616–623CrossRefPubMedGoogle Scholar
  4. 4.
    Dal Cin P, Sciot R, Polito P, Stas M (1997) Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas. Histopathology 31:222–225CrossRefPubMedGoogle Scholar
  5. 5.
    Debiec-Rychter M, Lasota J, Sarlomo-Rikala M, Kordek R, Miettinen M (2001) Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation. Cancer Genet Cytogenet 128:24–30CrossRefPubMedGoogle Scholar
  6. 6.
    Lee AH, Sworn MJ, Theaker JM (1993) Myofibroblastoma of breast: an immunohistochemical study. Histopathology 22:75–78PubMedCrossRefGoogle Scholar
  7. 7.
    Magro G, Michal M, Bisceglia M (2001) Benign spindle cell tumors of the mammary stroma: diagnostic criteria, classification, and histogenesis. Pathol Res Pract 197:453–466CrossRefPubMedGoogle Scholar
  8. 8.
    Magro G, Bisceglia M, Michal M, Eusebi V (2002) Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. Virchows Arch 440:249–260CrossRefPubMedGoogle Scholar
  9. 9.
    McMenamin, Fletcher CD (2001) Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. Am J Surg Pathol 25:1022–1029CrossRefPubMedGoogle Scholar
  10. 10.
    Nucci MR, Fletcher CD (1999) Myofibroblastoma of the breast: a distinctive benign stromal tumor. Pathol Case Rev 4:214–219Google Scholar
  11. 11.
    Pauwels P, Sciot R, Croiset F, Rutten H, Van den Berghe H, Dal Cin P (2001) Myofibroblastoma of the breast: genetic link with spindle cell lipoma. J Pathol 191:282–285CrossRefGoogle Scholar
  12. 12.
    Toker C, Tang C-K, Whitely JF (1981) Benign spindle cell breast tumor. Cancer 48:1615–1622PubMedCrossRefGoogle Scholar
  13. 13.
    Wargotz ES, Weiss SW, Norris HJ (1987) Myofibroblastoma of the breast: sixteen cases of a distinctive benign mesencymal tumor. Am J Surg Pathol 11:493–502PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Francesca Maggiani
    • 1
  • Maria Debiec-Rychter
    • 2
  • Guy Verbeeck
    • 3
  • Raf Sciot
    • 1
    • 4
  1. 1.Department of Morphology and Molecular Pathology, University HospitalCatholic University LeuvenLeuvenBelgium
  2. 2.Human Genetics, University HospitalCatholic University LeuvenLeuvenBelgium
  3. 3.Department of PathologySt. Elisabeth HospitalTurnhoutBelgium
  4. 4.Department of PathologyUniversity Hospital St. RafaëlLeuvenBelgium

Personalised recommendations