Virchows Archiv

, Volume 449, Issue 2, pp 244–247

Extramammary myofibroblastoma is genetically related to spindle cell lipoma

  • Francesca Maggiani
  • Maria Debiec-Rychter
  • Guy Verbeeck
  • Raf Sciot
Case Report

Abstract

Extramammary-type myofibroblastoma is a rare, benign spindle cell lesion, strictly resembling the breast counterpart, but occurring in extramammary sites, mainly in the inguinal/groin area. In this paper, we describe an extramammary-type myofibroblastoma in the groin of a 37-year-old male patient. The tumor showed a typical morphological and immunophenotypical profile, including staining for both CD34 and desmin. Dual-color interphase florescent in situ hybridization analysis revealed losses of RB/13q14 and FKHR/13q14 loci within tumor cells. The chromosome 13 rearrangements associated with the loss of the 13q14 chromosomal region are typically seen in spindle cell lipoma, and have been previously recognized in mammary myofibroblastoma, providing strong evidence for a pathogenetic link between these lesions.

Keywords

Mammary-type myofibroblastoma Spindle cell lipoma Immunohistochemistry Cytogenetics Chromosome 13 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Francesca Maggiani
    • 1
  • Maria Debiec-Rychter
    • 2
  • Guy Verbeeck
    • 3
  • Raf Sciot
    • 1
    • 4
  1. 1.Department of Morphology and Molecular Pathology, University HospitalCatholic University LeuvenLeuvenBelgium
  2. 2.Human Genetics, University HospitalCatholic University LeuvenLeuvenBelgium
  3. 3.Department of PathologySt. Elisabeth HospitalTurnhoutBelgium
  4. 4.Department of PathologyUniversity Hospital St. RafaëlLeuvenBelgium

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