Virchows Archiv

, Volume 448, Issue 5, pp 561–569 | Cite as

Solid–pseudopapillary neoplasms of the pancreas in men and women: do they differ?

  • Yu Takahashi
  • Nobuyoshi Hiraoka
  • Kaoru Onozato
  • Tatsuhiro Shibata
  • Tomoo Kosuge
  • Yuji Nimura
  • Yae Kanai
  • Setsuo HirohashiEmail author
Original Article


Solid–pseudopapillary neoplasms (SPNs) of the pancreas are uncommon and occur preferentially in young women. The question whether the features of SPNs occurring in men differ from those in women has not yet been studied. For a better understanding of the clinicopathological features of SPNs of both sexes, we studied a series of 14 tumors surgically resected at a Japanese hospital within a period of 14 years. This series was composed of seven men and seven women. All these SPNs demonstrated nuclear and cytoplasmic accumulation of β-catenin protein in immunohistochemistry and 86% of them had activating mutations of β-catenin gene. No pancreatic neuroendocrine tumors showed such immunohistochemical findings and genetic alterations. In our series, most SPNs in women showed encapsulation by thick fibrous tissue and massive degenerative changes. Most SPNs in men exhibited solid components without prominent degenerative changes, even though they were of a similar size to those in women. These findings suggest that SPNs in men tend to be a solid mass with slower progression of degenerative changes during their growth compared to that in women. Nuclear accumulation of β-catenin appears to be a useful marker of SPN, which allows male SPNs to be correctly diagnosed despite their less typical features.


Solid–pseudopapillary neoplasm of the pancreas β-Catenin Sex distribution 



The authors wish to thank Dr. Kazuaki Shimada, Dr. Tsuyoshi Sano, Dr. Yoshihiro Sakamoto, Dr. Hidenori Ojima, and Dr. Yuri A. Fukasawa for useful discussions and Dr. Yukihiro Yoshida and Mr. Taizo Masuda for their technical advice. This work was supported by a Grant-in-Aid for Third Term Comprehensive 10-year Strategy for Cancer Control from the Ministry of Health, Labor, and Welfare of Japan.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Yu Takahashi
    • 1
    • 3
  • Nobuyoshi Hiraoka
    • 1
  • Kaoru Onozato
    • 1
  • Tatsuhiro Shibata
    • 1
  • Tomoo Kosuge
    • 2
  • Yuji Nimura
    • 3
  • Yae Kanai
    • 1
  • Setsuo Hirohashi
    • 1
    Email author
  1. 1.Pathology DivisionNational Cancer Center Research InstituteChuo-kuJapan
  2. 2.Division of Hepato-Biliary and Pancreatic SurgeryNational Cancer Center HospitalTokyoJapan
  3. 3.Division of Surgical Oncology, Department of SurgeryNagoya University Graduate School of MedicineNagoyaJapan

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