Virchows Archiv

, Volume 449, Issue 1, pp 135–136 | Cite as

Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder

  • Aurelia Noske
  • Stefan PahlEmail author
Letter to the Editor

Dear Editor,

Although featuring a relatively simple microscopic anatomy, the gallbladder may give rise to a wide variety of malignant tumors. Beside pure forms of carcinomas, there are different admixed types. We report on a combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder, a histological subtype which, to the best of our knowledge, has not been described before.

Case report

A 81-year-old female patient was admitted to our hospital with a history of abdominal pain, weight loss, and jaundice for 3 months. At the time of admission, clinical signs of a fracture of the right femoral neck were also present. Cholelithiasis was diagnosed by abdominal ultrasound, whereas conventional radiography of the hip indicated a pathological fracture. The operative findings showed an advanced and unresectable large tumor of the gallbladder with infiltration of the extrahepatic bile ducts and liver. A palliative resection of the tumor with establishment of a biliodigestive...


Femoral Head Gallbladder Carcinoma Neuroendocrine Carcinoma Extrahepatic Bile Duct Adenosquamous Carcinoma 
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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Institute of PathologyCharité HospitalBerlinGermany

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